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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Eotaxin/CCL11 Antibody Picoband®

SKU : BHA21000466

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Mfr.No.	PB9569, PB9569-10ug, PB9569-Biotin, PB9569-Cy3, PB9569-Dylight488, PB9569-Dylight550, PB9569-Dylight594, PB9569-FITC, PB9569-HRP, PB9569-APC, PB9569-PE, PB9569-iFluor647, PB9569-carrier-free
Alternative Names	Eotaxin
Background	CCL11 (Chemokine (C-C motif) ligand 11), also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxin is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Eotaxin/CCL11 Antibody Picoband® catalog # PB9569. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In response to the presence of allergens, this protein ly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Host	Rabbit
Immunogen Region	E. coli-derived human Eotaxin recombinant protein (Position: G24-P97). Human Eotaxin shares 61.6% and 63% amino acid (aa) sequence identity with mouse and rat Eotaxin, respectively.
Isotype	Rabbit IgG
Molecular Weight	11 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Eotaxin;C-C motif chemokine 11;Eosinophil chemotactic protein;Small-inducible cytokine A11;CCL11;SCYA11;
Tissue Specificity	Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Uniprot	P51671
Gene Id	6356
Gene Name	CCL11
Sequence	Belongs to the intercrine beta (chemokine CC) family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, - ELISA, 0.1-0.5ug/ml, -

Reference	1. Menzies-Gow, A., Ying, S., Sabroe, I., Stubbs, V. L., Soler, D., Williams, T. J., Kay, A. B.Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.J. Immun. 169: 2712-2718, 2002. 2. Shin, H. D., Kim, L. H., Park, B. L., Jung, J. H., Kim, J. Y., Chung, I.-Y., Kim, J. S., Lee, J. H., Chung, S. H., Kim, Y. H., Park, H.-S., Choi, J. H., Lee, Y. M., Park, S. W., Choi, B. W., Hong, S.-J., Park, C.-S.Association of eotaxin gene family with asthma and serum total IgE.Hum. Molec. Genet. 12: 1279-1285, 2003. Note: Erratum: Hum. Molec. Genet. 12: 2083 only, 2003. 3. Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., Lucin, K. M., Czirr, E., and 11 others.The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Nature 477: 90-94, 2011.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000466-1	PB9569	100 ug	-	$370		Add to Cart
BHA21000466-2	PB9569-10ug	10 ug	Sample	$99		Add to Cart
BHA21000466-3	PB9569-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000466-4	PB9569-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000466-5	PB9569-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000466-6	PB9569-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000466-7	PB9569-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000466-8	PB9569-FITC	100 ug	FITC	$570		Add to Cart
BHA21000466-9	PB9569-HRP	100 ug	HRP	$570		Add to Cart
BHA21000466-10	PB9569-APC	100 ug	APC	$670		Add to Cart
BHA21000466-11	PB9569-PE	100 ug	PE	$670		Add to Cart
BHA21000466-12	PB9569-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000466-13	PB9569-carrier-free	100 ug	carrier-free	$370		Add to Cart

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