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Home / Primary Antibodies / Polyclonal Antibodies

Anti-EME1 Antibody Picoband®

SKU : BHA21000707

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Mfr.No.	PB9804, PB9804-10ug, PB9804-Biotin, PB9804-Cy3, PB9804-Dylight488, PB9804-Dylight550, PB9804-Dylight594, PB9804-FITC, PB9804-HRP, PB9804-APC, PB9804-PE, PB9804-iFluor647, PB9804-carrier-free
Alternative Names	Crossover junction endonuclease EME1
Background	Crossover junction endonuclease EME1 is an enzyme that in humans is encoded by the EME1 gene. It is mapped to 17q21.33. This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Also, this protein may be involved in repairing DNA damage and in maintaining genomic stability. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-EME1 Antibody Picoband® catalog # PB9804. Tested in Flow Cytometry, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human EME1, different from the related mouse sequence by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	62 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Crossover junction endonuclease EME1;3.1.22.-;MMS4 homolog;hMMS4;EME1;MMS4;
Tissue Specificity	Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96AY2
Gene Id	146956
Gene Name	EME1
Subcellular Location	Nucleus, nucleolus . Recruited to regions of DNA damage in S-phase cells.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human Immunocytochemistry, 0.5-1ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe)". 2. Abraham, J., Lemmers, B., Hande, M. P., Moynahan, M. E., Chahwan, C., Ciccia, A., Essers, J., Hanada, K., Chahwan, R., Khaw, A. K., McPherson, P., Shehabeldin, A., Laister, R., Arrowsmith, C., Kanaar, R., West, S. C., Jasin, M., Hakem, R. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J. 22: 6137-6147, 2003. 3. Ciccia A, Constantinou A, West SC (Jun 2003). "Identification and characterization of the human mus81-eme1 endonuclease". J Biol Chem 278 (27): 251728.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000707-1	PB9804	100 ug	-	$370		Add to Cart
BHA21000707-2	PB9804-10ug	10 ug	Sample	$99		Add to Cart
BHA21000707-3	PB9804-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000707-4	PB9804-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000707-5	PB9804-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000707-6	PB9804-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000707-7	PB9804-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000707-8	PB9804-FITC	100 ug	FITC	$570		Add to Cart
BHA21000707-9	PB9804-HRP	100 ug	HRP	$570		Add to Cart
BHA21000707-10	PB9804-APC	100 ug	APC	$670		Add to Cart
BHA21000707-11	PB9804-PE	100 ug	PE	$670		Add to Cart
BHA21000707-12	PB9804-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000707-13	PB9804-carrier-free	100 ug	carrier-free	$370		Add to Cart

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