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Home / Primary Antibodies / Polyclonal Antibodies

Anti-EIF5A Antibody Picoband®

SKU : BHA21004189

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Mfr.No.	A01727-4, A01727-4-10ug, A01727-4-Biotin, A01727-4-Cy3, A01727-4-Dylight488, A01727-4-Dylight550, A01727-4-Dylight594, A01727-4-FITC, A01727-4-HRP, A01727-4-APC, A01727-4-PE, A01727-4-iFluor647, A01727-4-carrier-free
Alternative Names	mitogen-activated protein kinase kinase 4
Background	Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. Eukaryotic initiation factor 5A (eIF5A) is an mRNA-binding protein that is involved in translation elongation and plays an important role in promoting translation of polyproline motifs. The eIF5A (eIF5A1) and eIF5A2 genes encode the two vertebrate eIF5A isoforms. While eIF5A1 is expressed constitutively in all tissues, eIF5A2 is mainly expressed in gonads. eIF5A and eIF5A2 are the only identified proteins that contain the distinctive amino acid hypusine, which is generated posttranslationally from lysine through a highly conserved polyamine metabolism pathway. eIF5A function and hypusine modification are both essential for cell proliferation, as knock down of eIF5A expression or blocking eIF5A hypusine modification suppresses cancer cell proliferation. Interestingly, eIF5A is an identified component of a tumor suppressor network of the polyamine-hypusine axis. Co-suppression of both eIF5A and adenosylmethionine decarboxylase 1 (AMD1) promotes lymphomagenesis in mice, while heterozygous deletions of the corresponding AMD1 and eIF5A genes often occur together in human lymphomas.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-EIF5A Antibody Picoband® catalog # A01727-4. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the on
Host	Rabbit
Immunogen Region	E.coli-derived human EIF5A recombinant protein (Position: R86-K154).
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK; MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1
Tissue Specificity	Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P63241
Gene Id	1984
Gene Name	EIF5A
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Mouse, Rat<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Doerfel, L. K., Wohlgemuth, I., Kothe, C., Peske, F., Urlaub, H., Rodnina, M. V. EF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science 339: 85-88, 2013. <br /><br />2. Faundes, V., Jennings, M. D., Crilly, S., Legraie, S., Withers, S. E., Cuvertino, S., Davies, S. J., Douglas, A. G. L., Fry, A. E., Harrison, V., Amiel, J., Lehalle, D., and 12 others. Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine. Nature Commun. 12: 833, 2021. <br /><br />3. Gutierrez, E., Shin, B.-S., Woolstenhulme, C. J., Kim, J.-R., Saini, P., Buskirk, A. R., Dever, T. E. eIF5A promotes translation of polyproline motifs. Molec. Cell 51: 35-45, 2013.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004189-1	A01727-4	-	100 ug	$370		Add to Cart
BHA21004189-2	A01727-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21004189-3	A01727-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004189-4	A01727-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004189-5	A01727-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004189-6	A01727-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004189-7	A01727-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004189-8	A01727-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21004189-9	A01727-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21004189-10	A01727-4-APC	APC	100 ug	$670		Add to Cart
BHA21004189-11	A01727-4-PE	PE	100 ug	$670		Add to Cart
BHA21004189-12	A01727-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004189-13	A01727-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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