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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ECSIT Antibody Picoband®

SKU : BHA21003667

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Mfr.No.	A07966-3, A07966-3-10ug, A07966-3-Biotin, A07966-3-Cy3, A07966-3-Dylight488, A07966-3-Dylight550, A07966-3-Dylight594, A07966-3-FITC, A07966-3-HRP, A07966-3-APC, A07966-3-PE, A07966-3-iFluor647, A07966-3-carrier-free
Alternative Names	DAZ associated protein 1
Background	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene. Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ECSIT Antibody Picoband® catalog # A07966-3. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	RNA-binding protein, which may be required during spermatogenesis.
Host	Rabbit
Immunogen Region	E.coli-derived human ECSIT recombinant protein (Position: E83-S339).
Isotype	Rabbit IgG
Molecular Weight	49 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	DAZ-associated protein 1; Deleted in azoospermia-associated protein 1; DAZAP1
Tissue Specificity	Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9BQ95
Gene Id	51295
Gene Name	ECSIT
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C. A., Ghosh, S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 13: 2059-2071, 1999. 2. Vogel, R. O., Janssen, R. J. R. J., van den Brand, M. A. M., Dieteren, C. E. J., Verkaart, S., Koopman, W. J. H., Willems, P. H. G. M., Pluk, W., van den Heuvel, L. P. W. J., Smeitink, J. A. M., Nijtmans, L. G. J. Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Genes Dev. 21: 615-624, 2007. 3. West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., Ghosh, S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472: 476-480, 2011.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003667-1	A07966-3	-	100 ug	$370		Add to Cart
BHA21003667-2	A07966-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003667-3	A07966-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003667-4	A07966-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003667-5	A07966-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003667-6	A07966-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003667-7	A07966-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003667-8	A07966-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003667-9	A07966-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003667-10	A07966-3-APC	APC	100 ug	$670		Add to Cart
BHA21003667-11	A07966-3-PE	PE	100 ug	$670		Add to Cart
BHA21003667-12	A07966-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003667-13	A07966-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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