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Home / Primary Antibodies / Polyclonal Antibodies

Anti-EAAT3/SLC1A1 Antibody Picoband®

SKU : BHA21002942

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Mfr.No.	A02367-1, A02367-1-10ug, A02367-1-Biotin, A02367-1-Cy3, A02367-1-Dylight488, A02367-1-Dylight550, A02367-1-Dylight594, A02367-1-FITC, A02367-1-HRP, A02367-1-APC, A02367-1-PE, A02367-1-iFluor647, A02367-1-carrier-free
Alternative Names	Neuronal acetylcholine receptor subunit alpha-5
Background	Solute carrier family 1 member 1, also called SLC1A1, is a protein that in humans is encoded by the SLC1A1 gene. By Southe analysis of a panel of human/rodent somatic cell hybrids and by fluorescence in situ hybridization (FISH), this gene is mapped to 9p24.2. This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are though to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-EAAT3/SLC1A1 Antibody Picoband® catalog # A02367-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Host	Rabbit
Immunogen Region	E.coli-derived human EAAT3/SLC1A1 recombinant protein (Position: Q160-F524).
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Neuronal acetylcholine receptor subunit alpha-5;CHRNA5;NACHRA5;
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P43005
Gene Id	6505
Gene Name	SLC1A1
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Berman, A. E., Chan, W. Y., Brennan, A. M., Reyes, R. C., Adler, B. L., Suh, S. W., Kauppinen, T. M., Edling, Y., Swanson, R. A. N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouse. Ann. Neurol. 69: 509-520, 2011.<br /><br />2. Myles-Worsley, M., Tiobech, J., Browning, S. R., Ko, J., Goodman, S., Gentile, K., Melhem, N., Byerley, W., Faraone, S. V., Middleton, F. A. Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. Am. J. Med. Genet. 162B: 87-95, 2013.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002942-1	A02367-1	-	100 ug	$370		Add to Cart
BHA21002942-2	A02367-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002942-3	A02367-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002942-4	A02367-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002942-5	A02367-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002942-6	A02367-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002942-7	A02367-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002942-8	A02367-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002942-9	A02367-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002942-10	A02367-1-APC	APC	100 ug	$670		Add to Cart
BHA21002942-11	A02367-1-PE	PE	100 ug	$670		Add to Cart
BHA21002942-12	A02367-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002942-13	A02367-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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