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Home / Primary Antibodies / Polyclonal Antibodies

Anti-E3 SUMO-protein ligase PIAS4 Antibody Picoband®

SKU : BHA21000987

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Mfr.No.	PB10082, PB10082-10ug, PB10082-Biotin, PB10082-Cy3, PB10082-Dylight488, PB10082-Dylight550, PB10082-Dylight594, PB10082-FITC, PB10082-HRP, PB10082-APC, PB10082-PE, PB10082-iFluor647, PB10082-carrier-free
Alternative Names	E3 SUMO-protein ligase PIAS4
Background	E3 SUMO-protein ligase PIAS4, also known as protein inhibitor of activated STAT protein 4 (PIAS4) or protein inhibitor of activated STAT protein gamma (PIASg or PIASy), is an enzyme that in humans is encoded by the PIAS4 gene. This gene is mapped to 19p13.3. This gene plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. It also functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This gene involved in gene silencing.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-E3 SUMO-protein ligase PIAS4 Antibody Picoband® catalog # PB10082. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, includin
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PIAS4, different from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	E3 SUMO-protein ligase PIAS4;6.3.2.-;PIASy;Protein inhibitor of activated STAT protein 4;Protein inhibitor of activated STAT protein gamma;PIAS-gamma;PIAS4;PIASG;
Tissue Specificity	Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8N2W9
Gene Id	51588
Gene Name	PIAS4
Subcellular Location	Nucleus, PML body . Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Bischof, O., Schwambo, K., Martin, N., Weer, A., Sustmann, C., Grosschedl, R., Dejean, A. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Molec. Cell 22: 783-794, 2006. 2. Galanty, Y., Belotserkovskaya, R., Coates, J., Polo, S., Miller, K. M., Jackson, S. P. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 462: 935-939, 2009. 3. Sachdev, S., Bruhn, L., Sieber, H., Pichler, A., Melchior, F., Grosschedl, R. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 15: 3088-3103, 2001.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000987-1	PB10082	100 ug	-	$370		Add to Cart
BHA21000987-2	PB10082-10ug	10 ug	Sample	$99		Add to Cart
BHA21000987-3	PB10082-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000987-4	PB10082-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000987-5	PB10082-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000987-6	PB10082-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000987-7	PB10082-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000987-8	PB10082-FITC	100 ug	FITC	$570		Add to Cart
BHA21000987-9	PB10082-HRP	100 ug	HRP	$570		Add to Cart
BHA21000987-10	PB10082-APC	100 ug	APC	$670		Add to Cart
BHA21000987-11	PB10082-PE	100 ug	PE	$670		Add to Cart
BHA21000987-12	PB10082-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000987-13	PB10082-carrier-free	100 ug	carrier-free	$370		Add to Cart

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