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Home / Primary Antibodies / Polyclonal Antibodies

Anti-E1 Ubiquitin Activating Enzyme/UBA1 Antibody Picoband®

SKU : BHA21000804

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Mfr.No.	PB9904, PB9904-10ug, PB9904-Biotin, PB9904-Cy3, PB9904-Dylight488, PB9904-Dylight550, PB9904-Dylight594, PB9904-FITC, PB9904-HRP, PB9904-APC, PB9904-PE, PB9904-iFluor647, PB9904-carrier-free
Alternative Names	Ubiquitin-like modifier-activating enzyme 1
Background	Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. The protein encoded by this gene catalyzes the first step in ubiquitin conjugation, or ubiquitination, to mark cellular proteins for degradation. Specifically, UBA1 catalyzes the ATP-dependent adenylation of ubiquitin (Ub), thereby forming a thioester bond between the two. It also continues to participate in subsequent steps of ubiquination as a Ub carrier. UBA1 is one of only two human ubiquitin-activating enzymes (E1), the other being UBA6, and thus is largely responsible for protein ubiquitination in humans. Through its central role in ubiquitination, UBA1 has been linked to cell cycle regulation, endocytosis, signal transduction, apoptosis, DNA damage repair, and transcriptional regulation. Additionally, UBE1 helps regulate the NEDD8 pathway, thus implicating it in protein folding, as well as mitigating the depletion of ubiquitin levels during stress.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-E1 Ubiquitin Activating Enzyme/UBA1 Antibody Picoband® catalog # PB9904. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human UBA1, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	117 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Ubiquitin-like modifier-activating enzyme 1;6.2.1.45 ;Protein A1S9;Ubiquitin-activating enzyme E1;UBA1;A1S9T, UBE1;
Tissue Specificity	Detected in erythrocytes (at protein level). Ubiquitous. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P22314
Gene Id	7317
Gene Name	UBA1
Subcellular Location	Cytoplasm . Mitochondrion . Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. "Entrez Gene: ubiquitin-like modifier activating enzyme 1". 2. Moudry P, Lukas C, Macurek L, Hanzlikova H, Hodny Z, Lukas J, Bartek J (Apr 2012). "Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage". Cell Cycle 11 (8): 157382.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000804-1	PB9904	100 ug	-	$370		Add to Cart
BHA21000804-2	PB9904-10ug	10 ug	Sample	$99		Add to Cart
BHA21000804-3	PB9904-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000804-4	PB9904-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000804-5	PB9904-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000804-6	PB9904-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000804-7	PB9904-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000804-8	PB9904-FITC	100 ug	FITC	$570		Add to Cart
BHA21000804-9	PB9904-HRP	100 ug	HRP	$570		Add to Cart
BHA21000804-10	PB9904-APC	100 ug	APC	$670		Add to Cart
BHA21000804-11	PB9904-PE	100 ug	PE	$670		Add to Cart
BHA21000804-12	PB9904-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000804-13	PB9904-carrier-free	100 ug	carrier-free	$370		Add to Cart

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