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Home / Primary Antibodies / Polyclonal Antibodies

Anti-E Cadherin 1/CDH1 Antibody Picoband®

SKU : BHA21000457

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Mfr.No.	PB9561, PB9561-10ug, PB9561-Biotin, PB9561-Cy3, PB9561-Dylight488, PB9561-Dylight550, PB9561-Dylight594, PB9561-FITC, PB9561-HRP, PB9561-APC, PB9561-PE, PB9561-iFluor647, PB9561-carrier-free
Alternative Names	Cadherin-1
Background	CDH1 (Cadherin 1), also known as ECAD or UVO, is a protein that in humans is encoded by the CDH1 gene. Cadherin-1 is a classical member of the cadherin superfamily. By Southe analysis of DNA from a panel of mouse-human somatic cell hybrids, Mansouri et al. (1987, 1988) assigned the UVO gene to 16q (16p11-qter). Frebourg et al. (2006) found that in human embryos CDH1 is highly expressed at 4 and 5 weeks in the frontonasal prominence and at 6 weeks in the lateral and medial nasal prominences, and is therefore expressed during critical stages of lip and palate development. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-E Cadherin 1/CDH1 Antibody Picoband® catalog # PB9561. Tested in ELISA, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regul
Host	Rabbit
Immunogen Region	E.coli-derived human E Cadherin recombinant protein (Position: A286-A703). Human E Cadherin shares 79.7% and 80.9% amino acid (aa) sequence identity with mouse and rat E Cadherin, respectively.
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cadherin-1;CAM 120/80;Epithelial cadherin;E-cadherin;Uvomorulin;CD324;E-Cad/CTF1;E-Cad/CTF2;E-Cad/CTF3;CDH1;CDHE, UVO;
Tissue Specificity	Non-neural epithelial tissues.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P12830
Gene Id	999
Gene Name	CDH1
Sequence	Contains 5 cadherin domains.
Subcellular Location	Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human, Mouse, Rat - Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Immunofluorescence, 5ug/ml, Human, Mouse ELISA, 0.1-0.5ug/ml, -

Reference	1. Agiostratidou G., Muros R.M., Shioi J., Marambaud P., Robakis N.K. The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. J. Neurochem. 96:1182-1188(2006). 2. Frebourg, T., Oliveira, C., Hochain, P., Karam, R., Manouvrier, S., Graziadio, C., Vekemans, M., Hartmann, A., Baert-Desurmont, S., Alexandre, C., Lejeune Dumoulin, S., Marroni, C., and 16 others. Cleft lip/palate and CDH1/E-cadherin mutation in families with hereditary diffuse gastric cancer. J. Med. Genet. 43: 138-142, 2006. 3. Mansouri, A., Goodfellow, P. N., Kemler, R. Molecular cloning and chromosomal localization of the human cell adhesion molecule uvomorulin (UVO). (Abstract) Cytogenet. Cell Genet. 46: 655, 1987. 4. Mansouri, A., Spurr, N., Goodfellow, P. N., Kemler, R. Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin. Differentiation 38: 67-71, 1988.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000457-1	PB9561	100 ug	-	$370		Add to Cart
BHA21000457-2	PB9561-10ug	10 ug	Sample	$99		Add to Cart
BHA21000457-3	PB9561-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000457-4	PB9561-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000457-5	PB9561-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000457-6	PB9561-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000457-7	PB9561-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000457-8	PB9561-FITC	100 ug	FITC	$570		Add to Cart
BHA21000457-9	PB9561-HRP	100 ug	HRP	$570		Add to Cart
BHA21000457-10	PB9561-APC	100 ug	APC	$670		Add to Cart
BHA21000457-11	PB9561-PE	100 ug	PE	$670		Add to Cart
BHA21000457-12	PB9561-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000457-13	PB9561-carrier-free	100 ug	carrier-free	$370		Add to Cart

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