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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DUSP3 Picoband® Antibody

SKU : BHA21002526

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Mfr.No.	A06135, A06135-10ug, A06135-Biotin, A06135-Cy3, A06135-Dylight488, A06135-Dylight550, A06135-Dylight594, A06135-FITC, A06135-HRP, A06135-APC, A06135-PE, A06135-iFluor647, A06135-carrier-free
Alternative Names	dual specificity phosphatase 3
Background	Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene. It is mapped to 17q21.31. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-DUSP3 Picoband® Antibody catalog # A06135. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Host	Rabbit
Immunogen Region	E.coli-derived human DUSP3 recombinant protein (Position: S4-P185).
Isotype	Rabbit IgG
Molecular Weight	20 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR; DUSP3; VHR
Tissue Specificity	Testis specific.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P51452
Gene Id	1845
Gene Name	DUSP3
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Alonso, A., Rahmouni, S., Williams, S., van Stipdonk, M., Jaroszewski, L., Godzik, A., Abraham, R. T., Schoenberger, S. P., Mustelin, T. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nature Immun. 4: 44-48, 2003. <br /><br />2. Ishibashi, T., Bottaro, D. P., Chan, A., Miki, T., Aaronson, S. A. Expression cloning of a human dual-specificity phosphatase. Proc. Nat. Acad. Sci. 89: 12170-12174, 1992.<br /><br />3. Jones, K. A., Black, D. M., Brown, M. A., Griffiths, B. L., Nicolai, H. M., Chambers, J. A., Bonjardim, M., Xu, C.-F., Boyd, M., McFarlane, R., Ko, B., Poustka, A., North, M. A., Schalkwyk, L., Lehrach, H., Solomon, E. The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase. Hum. Molec. Genet. 3: 1927-1934, 1994.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002526-1	A06135	-	100 ug	$370		Add to Cart
BHA21002526-2	A06135-10ug	Sample	10 ug	$99		Add to Cart
BHA21002526-3	A06135-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002526-4	A06135-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002526-5	A06135-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002526-6	A06135-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002526-7	A06135-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002526-8	A06135-FITC	FITC	100 ug	$570		Add to Cart
BHA21002526-9	A06135-HRP	HRP	100 ug	$570		Add to Cart
BHA21002526-10	A06135-APC	APC	100 ug	$670		Add to Cart
BHA21002526-11	A06135-PE	PE	100 ug	$670		Add to Cart
BHA21002526-12	A06135-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002526-13	A06135-carrier-free	carrier-free	100 ug	$370		Add to Cart

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