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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DR4/TNFRSF10A Antibody Picoband®

SKU : BHA21001054

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Mfr.No.	A02152, A02152-10ug, A02152-Biotin, A02152-Cy3, A02152-Dylight488, A02152-Dylight550, A02152-Dylight594, A02152-FITC, A02152-HRP, A02152-APC, A02152-PE, A02152-iFluor647, A02152-carrier-free
Alternative Names	Tumor necrosis factor receptor superfamily member 10A
Background	TNFRSF10A (Tumor Necrosis Factor Receptor Subfamily Member 10A), also known as APO2, DR4 or TRAILR1, is a protein that in humans is encoded by the TNFRSF10A gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-DR4/TNFRSF10A Antibody Picoband® catalog # A02152. Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DR4.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 10A;Death receptor 4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAIL-R1;CD261;TNFRSF10A;APO2, DR4, TRAILR1;
Tissue Specificity	Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	O00220
Gene Id	8797
Gene Name	TNFRSF10A
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml<br>

Reference	1. Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 538697.<br /><br />2. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 1113.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001054-1	A02152	100 ug	-	$370		Add to Cart
BHA21001054-2	A02152-10ug	10 ug	Sample	$99		Add to Cart
BHA21001054-3	A02152-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001054-4	A02152-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001054-5	A02152-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001054-6	A02152-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001054-7	A02152-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001054-8	A02152-FITC	100 ug	FITC	$570		Add to Cart
BHA21001054-9	A02152-HRP	100 ug	HRP	$570		Add to Cart
BHA21001054-10	A02152-APC	100 ug	APC	$670		Add to Cart
BHA21001054-11	A02152-PE	100 ug	PE	$670		Add to Cart
BHA21001054-12	A02152-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001054-13	A02152-carrier-free	100 ug	carrier-free	$370		Add to Cart

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