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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DPP6 (extracellular) Antibody

SKU : BHA21301043

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Alomone Labs

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Mfr.No.	APC-146, APC-146-CF_0.2 ml, APC-146_0.2 ml, APC-146_25 mcl, APC-146_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Human
Background	Dipeptidyl-peptidase 6 (DPP6) is a type II membrane glycoprotein1 which is a part of the dipeptydil aminopeptidase-like proteins (DPPLs) subfamily. It is an auxiliary glycoproteinic subunit of voltage-dependent K+ channel 4 (KV4.x), that has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. It regulates sub-threshold, A-type K+ currents, and is important for the enhancement and localization of KV4.2 channels2.DPPLs are a subgroup of the larger prolyl oligopeptidase family. A loss-of-function mutation at their enzymatic serine renders them incapable of cleaving peptides. Notable DPPLs include DPP8, DPP9, and DPPIV - the latter is known to regulate several key functions in varied systems, ranging from immune to CNS1,3.Alternative mRNA splicing of the DPP6 gene (part of the di-genic DPLP group that also consists DPP10) gives rise to several isoforms that differ in their N-terminal (DPP6a, DPP6K, DPP6S, DPP6L DPP6E)4.DPP6 proteins are widely expressed throughout both of the nervous systems - albeit much more predominantly in the CNS - and are known to play a major role in neurogenesis and neurodevelopment5.Deletion mutations and haplo-insufficiency of the DPP6 gene has been shown to be associated with autism spectrum disorder, Gilles de la Tourette syndrome, dominant microcephaly and mental retardation5,6. Endometriosis - a condition characterized by extra-uteral endometrial glands that affects one tenth of fertile women population - has been linked with DPP6 in genome wide associations studies (GWASs)7.
Clonality	Polyclonal
Description	Anti-DPP6 (extracellular) Antibody (#APC-146) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize DPP6 from rat, mouse, and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Extracellular, C-terminus
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Dipeptidyl peptidase 6, Dipeptidyl aminopeptidase-like protein 6, DPP VI, DPPX, VF2
UNSPSC Code	41116161
Note	Homology: Rat, mouse - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC146 Specifictiy: DPP6 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P42658
Gene Id	1804
Target	Dipeptidyl peptidase 6, Dipeptidyl aminopeptidase-like protein 6, DPP VI, DPPX, VF2
Sequence	(C)KKHEDESEAWLHR, corresponding to amino acid residues 414-426 of human DPP6

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IHC, WB
Dilution	1:400

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301043-1	APC-146-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21301043-2	APC-146_0.2 ml	0.2 ml	$795		Add to Cart
BHA21301043-3	APC-146_25 mcl	25 mcl	$597		Add to Cart
BHA21301043-4	APC-146_50 mcl	50 mcl	$697		Add to Cart

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