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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Dopamine Receptor D5/DRD5 Antibody Picoband®

SKU : BHA21007392

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Mfr.No.	PA2204, PA2204-10ug, PA2204-Biotin, PA2204-Cy3, PA2204-Dylight488, PA2204-Dylight550, PA2204-Dylight594, PA2204-FITC, PA2204-HRP, PA2204-APC, PA2204-PE, PA2204-iFluor647, PA2204-carrier-free
Alternative Names	D(1B) dopamine receptor
Background	D (1B) dopamine receptor (DRD5), also called DRD1B or DRD1L2 is a protein that in humans is encoded by the DRD5 gene. This gene is mapped to 4p16.1. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. Compared with DRD1, DRD5 displayed a higher affinity for dopamine and was able to stimulate a biphasic rather than a monophasic intracellular accumulation of cAMP.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Dopamine Receptor D5/DRD5 Antibody catalog # PA2204. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse Dopamine Receptor D5, different from the related rat sequence by two amino acids, and from the related human sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	53 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	D (1B) dopamine receptor;D (5) dopamine receptor;Dopamine D5 receptor;Drd5;
Tissue Specificity	Brain, liver, placenta, lymphocytes and erythrocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q8BLD9
Gene Name	DRD5
Sequence	Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family.
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br>

Reference	1. Li, H., Armando, I., Yu, P., Escano, C., Mueller, S. C., Asico, L., Pascua, A., Lu, Q., Wang, X., Villar, V. A. M., Jones, J. E., Wang, Z., and 9 others. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells. J. Clin. Invest. 118: 2180-2189, 2008. Note: Erratum: J. Clin. Invest. 118: 2986 only, 2008.<br /><br />2. Lowe, N., Kirley, A., Hawi, Z., Sham, P., Wickham, H., Kratochvil, C. J., Smith, S. D., Lee, S. Y., Levy, F., Kent, L., Middle, F., Rohde, L. A., and 20 others. Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. Am. J. Hum. Genet. 74: 348-356, 2004.<br /><br />3. Misbahuddin, A., Placzek, M. R., Chaudhuri, K. R., Wood, N. W., Bhatia, K. P., Waer, T. T. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. Neurology 58: 124-126, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007392-1	PA2204	-	100 ug	$370		Add to Cart
BHA21007392-2	PA2204-10ug	Sample	10 ug	$99		Add to Cart
BHA21007392-3	PA2204-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007392-4	PA2204-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007392-5	PA2204-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007392-6	PA2204-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007392-7	PA2204-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007392-8	PA2204-FITC	FITC	100 ug	$570		Add to Cart
BHA21007392-9	PA2204-HRP	HRP	100 ug	$570		Add to Cart
BHA21007392-10	PA2204-APC	APC	100 ug	$670		Add to Cart
BHA21007392-11	PA2204-PE	PE	100 ug	$670		Add to Cart
BHA21007392-12	PA2204-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007392-13	PA2204-carrier-free	carrier-free	100 ug	$370		Add to Cart

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