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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Dnmt1 Antibody Picoband®

SKU : BHA21004495

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Mfr.No.	A00172-3, A00172-3-10ug, A00172-3-Biotin, A00172-3-Cy3, A00172-3-Dylight488, A00172-3-Dylight550, A00172-3-Dylight594, A00172-3-FITC, A00172-3-HRP, A00172-3-APC, A00172-3-PE, A00172-3-iFluor647, A00172-3-carrier-free
Alternative Names	DNA methyltransferase 1
Background	DNA (cytosine-5)-methyltransferase 1 is an enzyme that in humans is encoded by the DNMT1 gene. This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation pattes following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation pattes are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Dnmt1 Antibody Picoband® catalog # A00172-3. Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation patte in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chro
Host	Rabbit
Immunogen Region	E.coli-derived mouse Dnmt1 recombinant protein (Position: Q509-Q1577).
Isotype	Rabbit IgG
Molecular Weight	200 kDa
Reactivity	Mouse
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	DNA (cytosine-5)-methyltransferase 1; Dnmt1; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMT; DNMT1; AIM; CXXC9; DNMT
Tissue Specificity	Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P13864
Gene Id	13433
Gene Name	Dnmt1
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Bigey, P., Ramchandani, S., Theberge, J., Araujo, F. D., Szyf, M. Transcriptional regulation of the human DNA methyltransferase (dnmt1) gene. Gene 242: 407-418, 2000. <br /><br />2. Chen, T., Hevi, S., Gay, F., Tsujimoto, N., He, T., Zhang, B., Ueda, Y., Li, E. Complete activation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nature Genet. 39: 391-396, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004495-1	A00172-3	-	100 ug	$370		Add to Cart
BHA21004495-2	A00172-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004495-3	A00172-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004495-4	A00172-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004495-5	A00172-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004495-6	A00172-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004495-7	A00172-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004495-8	A00172-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004495-9	A00172-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004495-10	A00172-3-APC	APC	100 ug	$670		Add to Cart
BHA21004495-11	A00172-3-PE	PE	100 ug	$670		Add to Cart
BHA21004495-12	A00172-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004495-13	A00172-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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