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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DNA PKcs/PRKDC Antibody Picoband®

SKU : BHA21007204

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Mfr.No.	PA1970, PA1970-10ug, PA1970-Biotin, PA1970-Cy3, PA1970-Dylight488, PA1970-Dylight550, PA1970-Dylight594, PA1970-FITC, PA1970-HRP, PA1970-APC, PA1970-PE, PA1970-iFluor647, PA1970-carrier-free
Alternative Names	DNA-dependent protein kinase catalytic subunit
Background	PRKDC (Protein Kinase DNA-Activated Catalytic Subunit), also called DNAPK, HYRC1, p350 or DNPK1, is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Satoh et al. (1997) mapped the MCM4 gene to 8q11.2 by FISH. Based on the close proximity of the PRKDC and MCM4 genes, it was assumed that the PRKDC gene also maps to this location. Anderson and Lees-Miller (1992) noted that DNA-PK had been shown in vitro to phosphorylate several transcription factors, suggesting that it functions in cell homeostasis by modulating transcription. Daniel et al. (1999) demonstrated that the PRKDC protein participates in retroviral DNA integration, which is catalyzed by the viral protein integrase.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-DNA PKcs/PRKDC Antibody catalog # PA1970. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V (D)J recombination. Must be bound to DNA to express its catalytic propert
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DNA PKcs.
Isotype	Rabbit IgG
Molecular Weight	460 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	DNA-dependent protein kinase catalytic subunit;DNA-PK catalytic subunit;DNA-PKcs;2.7.11.1;DNPK1;p460;PRKDC;HYRC, HYRC1;
Tissue Specificity	Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P78527
Gene Name	PRKDC
Sequence	Belongs to the PI3/PI4-kinase family.
Subcellular Location	Nucleus. Nucleus, nucleolus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Anderson, C. W., Lees-Miller, S. P. The nuclear serine/threonine protein kinase DNA-PK. Crit. Rev. Eukaryot. Gene Expr. 2: 283-314, 1992. <br /><br />2. Daniel, R., Katz, R. A., Skalka, A. M. A role for DNA-PK in retroviral DNA integration. Science 284: 644-647, 1999. <br /><br />3. Satoh, T., Tsuruga, H., Yabuta, N., Ishidate, M., Jr., Nojima, H. Assignment of the human CDC21 (MCM4) gene to chromosome 8q11.2. Genomics 46: 525-526, 1997. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007204-1	PA1970	-	100 ug	$370		Add to Cart
BHA21007204-2	PA1970-10ug	Sample	10 ug	$99		Add to Cart
BHA21007204-3	PA1970-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007204-4	PA1970-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007204-5	PA1970-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007204-6	PA1970-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007204-7	PA1970-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007204-8	PA1970-FITC	FITC	100 ug	$570		Add to Cart
BHA21007204-9	PA1970-HRP	HRP	100 ug	$570		Add to Cart
BHA21007204-10	PA1970-APC	APC	100 ug	$670		Add to Cart
BHA21007204-11	PA1970-PE	PE	100 ug	$670		Add to Cart
BHA21007204-12	PA1970-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007204-13	PA1970-carrier-free	carrier-free	100 ug	$370		Add to Cart

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