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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DMRT1 Antibody Picoband®

SKU : BHA21000517

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Mfr.No.	RP1083, RP1083-10ug, RP1083-Biotin, RP1083-Cy3, RP1083-Dylight488, RP1083-Dylight550, RP1083-Dylight594, RP1083-FITC, RP1083-HRP, RP1083-APC, RP1083-PE, RP1083-iFluor647, RP1083-carrier-free
Alternative Names	Doublesex- and mab-3-related transcription factor 1
Background	Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene. This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression patte. Defective testicular development and XY feminization occur when this gene is hemizygous.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-DMRT1 Antibody catalog # RP1083. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DMRT1, different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Doublesex- and mab-3-related transcription factor 1;DM domain expressed in testis protein 1;DMRT1;DMT1;
Tissue Specificity	Testis-specific. Expressed in prostate cancer (at protein level). .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9Y5R6
Gene Id	1761
Gene Name	DMRT1
Sequence	Belongs to the DMRT family.
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human

Reference	1. "Entrez Gene: DMRT1 doublesex and mab-3 related transcription factor 1". 2. Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). "Evidence for evolutionary conservation of sex-determining genes".Nature 391 (6668): 6915. 3. Smith CA, Roeszler KN, Ohnesorg T, Cummins DM, Farlie PG, Doran TJ, Sinclair AH (August 2009). "The avian Z-linked gene DMRT1 is required for male sex determination in the chicken". Nature 461(7261): 26771.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000517-1	RP1083	100 ug	-	$370		Add to Cart
BHA21000517-2	RP1083-10ug	10 ug	Sample	$99		Add to Cart
BHA21000517-3	RP1083-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000517-4	RP1083-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000517-5	RP1083-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000517-6	RP1083-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000517-7	RP1083-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000517-8	RP1083-FITC	100 ug	FITC	$570		Add to Cart
BHA21000517-9	RP1083-HRP	100 ug	HRP	$570		Add to Cart
BHA21000517-10	RP1083-APC	100 ug	APC	$670		Add to Cart
BHA21000517-11	RP1083-PE	100 ug	PE	$670		Add to Cart
BHA21000517-12	RP1083-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000517-13	RP1083-carrier-free	100 ug	carrier-free	$370		Add to Cart

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