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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DIO1 Antibody Picoband®

SKU : BHA21002642

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Mfr.No.	A04612, A04612-10ug, A04612-Biotin, A04612-Cy3, A04612-Dylight488, A04612-Dylight550, A04612-Dylight594, A04612-FITC, A04612-HRP, A04612-APC, A04612-PE, A04612-iFluor647, A04612-carrier-free
Alternative Names	iodothyronine deiodinase 1
Background	Type I iodothyronine deiodinase is a protein that in humans is encoded by the DIO1 gene. It is mapped to 1p32.3. The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alteatively spliced transcript variants have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-DIO1 Antibody Picoband® catalog # A04612. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and
Host	Rabbit
Immunogen Region	E.coli-derived human DIO1 recombinant protein (Position: K137-S249).
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Type I iodothyronine deiodinase; 5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase; DIO1; ITDI1; TXDI1
Tissue Specificity	Widely expressed in adult (at protein level) and fetal tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P49895
Gene Id	1733
Gene Name	DIO1
Subcellular Location	Endoplasmic reticulum membrane. Single-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human, Mouse<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Berry, M. J., Banu, L., Larsen, P. R. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349: 438-440, 1991.<br /><br />2. Berry, M. J., Grieco, D., Taylor, B. A., Maia, A. L., Kieffer, J. D., Beamer, W., Glover, E., Poland, A., Larsen, P. R. Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5-prime deiodinase deficiency. J. Clin. Invest. 92: 1517-1528, 1993.<br /><br />3. de Jong, F. J., Peeters, R. P., den Heijer, T., van der Deure, W. M., Hofman, A., Uitterlinden, A. G., Visser, T. J., Breteler, M. M. B. The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe. J. Clin. Endocr. Metab. 92: 636-640, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002642-1	A04612	-	100 ug	$370		Add to Cart
BHA21002642-2	A04612-10ug	Sample	10 ug	$99		Add to Cart
BHA21002642-3	A04612-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002642-4	A04612-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002642-5	A04612-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002642-6	A04612-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002642-7	A04612-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002642-8	A04612-FITC	FITC	100 ug	$570		Add to Cart
BHA21002642-9	A04612-HRP	HRP	100 ug	$570		Add to Cart
BHA21002642-10	A04612-APC	APC	100 ug	$670		Add to Cart
BHA21002642-11	A04612-PE	PE	100 ug	$670		Add to Cart
BHA21002642-12	A04612-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002642-13	A04612-carrier-free	carrier-free	100 ug	$370		Add to Cart

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