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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Dickkopf-related protein 1 DKK1 Antibody Picoband®

SKU : BHA21006809

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Mfr.No.	PA1462, PA1462-10ug, PA1462-Biotin, PA1462-Cy3, PA1462-Dylight488, PA1462-Dylight550, PA1462-Dylight594, PA1462-FITC, PA1462-HRP, PA1462-APC, PA1462-PE, PA1462-iFluor647, PA1462-carrier-free
Alternative Names	Dickkopf-related protein 1
Background	DKK1, Dickkopf-related protein 1, is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. By genomic sequence analysis, determined that the DKK1 gene contains 4 exons. The DKK1 gene is mapped to 10q11.2 using FISH. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Dickkopf-related protein 1 DKK1 Antibody catalog # PA1462. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a teary complex with the transmembrane protein KREMEN that promotes intealization of LRP5/6. DKKs play an important role in vertebrate development, where they
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human DKK1, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dickkopf-related protein 1;Dickkopf-1;Dkk-1;hDkk-1;SK;DKK1;UNQ492/PRO1008;
Tissue Specificity	Placenta.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O94907
Gene Name	DKK1
Sequence	Belongs to the dickkopf family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Fedi, P., Bafico, A., Soria, A. N., Burgess, W. H., Miki, T., Bottaro, D. P., Kraus, M. H., Aaronson, S. A.Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.J. Biol. Chem. 274: 19465-19472, 1999.<br /><br />2. Roessler, E., Du, Y., Glinka, A., Dutra, A., Niehrs, C., Muenke, M.The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. Cytogenet. Cell Genet. 89: 220-224, 2000.<br /><br />3. Tian, E., Zhan, F., Walker, R., Rasmussen, E., Ma, Y., Barlogie, B., Shaughnessy, J. D., Jr.The role of Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.New Eng. J. Med. 349: 2483-2494, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006809-1	PA1462	-	100 ug	$370		Add to Cart
BHA21006809-2	PA1462-10ug	Sample	10 ug	$99		Add to Cart
BHA21006809-3	PA1462-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006809-4	PA1462-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006809-5	PA1462-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006809-6	PA1462-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006809-7	PA1462-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006809-8	PA1462-FITC	FITC	100 ug	$570		Add to Cart
BHA21006809-9	PA1462-HRP	HRP	100 ug	$570		Add to Cart
BHA21006809-10	PA1462-APC	APC	100 ug	$670		Add to Cart
BHA21006809-11	PA1462-PE	PE	100 ug	$670		Add to Cart
BHA21006809-12	PA1462-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006809-13	PA1462-carrier-free	carrier-free	100 ug	$370		Add to Cart

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