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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Dicer/DICER1 Antibody Picoband®

SKU : BHA21000079

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Mfr.No.	RP1044, RP1044-10ug, RP1044-Biotin, RP1044-Cy3, RP1044-Dylight488, RP1044-Dylight550, RP1044-Dylight594, RP1044-FITC, RP1044-HRP, RP1044-APC, RP1044-PE, RP1044-iFluor647, RP1044-carrier-free
Alternative Names	Endoribonuclease Dicer
Background	Dicer (DICER1), also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. It is mapped to 14q32.13. The DICER1 gene, a member of the ribonuclease III (RNaseIII) family, is involved in the generation of microRNAs (miRNAs), which modulate gene expression at the posttranscriptional level. DICER1 possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus DICER, also known as helicase-MOI, is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. In addition, DICER1 is required for formation of the RNA induced silencing complex (RISC). It also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Dicer/DICER1 Antibody catalog # RP1044. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three n
Host	Rabbit
Immunogen Region	E.coli-derived human Dicer recombinant protein (Position: M1-N195). Human Dicer shares 94% amino acid (aa) sequence identity with mouse Dicer.
Isotype	Rabbit IgG
Molecular Weight	250 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Endoribonuclease Dicer;3.1.26.3;Helicase with RNase motif;Helicase MOI;DICER1;DICER, HERNA, KIAA0928;
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q9UPY3
Gene Id	23405
Gene Name	DICER1
Sequence	Belongs to the helicase family. Dicer subfamily.
Subcellular Location	Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Hutvagner, G., McLachlan, J., Pasquinelli, A. E., Balint, E., Tuschl, T., Zamore, P. D. A cellular function for the RNA-interference enzyme dicer in the maturation of the let-7 small temporal RNA. Science 293: 834-838, 2001. 2. Matsuda, S., Ichigotani, Y., Okuda, T., Irimura, T., Nakatsugawa, S., Hamaguchi, M. Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. Biochim. Biophys. Acta 1490: 163-169, 2000.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000079-1	RP1044	100 ug	-	$370		Add to Cart
BHA21000079-2	RP1044-10ug	10 ug	Sample	$99		Add to Cart
BHA21000079-3	RP1044-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000079-4	RP1044-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000079-5	RP1044-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000079-6	RP1044-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000079-7	RP1044-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000079-8	RP1044-FITC	100 ug	FITC	$570		Add to Cart
BHA21000079-9	RP1044-HRP	100 ug	HRP	$570		Add to Cart
BHA21000079-10	RP1044-APC	100 ug	APC	$670		Add to Cart
BHA21000079-11	RP1044-PE	100 ug	PE	$670		Add to Cart
BHA21000079-12	RP1044-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000079-13	RP1044-carrier-free	100 ug	carrier-free	$370		Add to Cart

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