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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Desmoglein 2/DSG2 Antibody Picoband®

SKU : BHA21002408

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Mfr.No.	A02035, A02035-10ug, A02035-Biotin, A02035-Cy3, A02035-Dylight488, A02035-Dylight550, A02035-Dylight594, A02035-FITC, A02035-HRP, A02035-APC, A02035-PE, A02035-iFluor647, A02035-carrier-free
Alternative Names	desmoglein 2
Background	Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Desmoglein 2/DSG2 Antibody Picoband® catalog # A02035. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Host	Rabbit
Immunogen Region	E.coli-derived human Desmoglein 2/DSG2 recombinant protein (Position: L24-E1020).
Isotype	Rabbit IgG
Molecular Weight	160 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Desmoglein-2; Cadherin family member 5; HDGC; DSG2; CDHF5
Tissue Specificity	All of the tissues tested and carcinomas.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q14126
Gene Id	1829
Gene Name	DSG2
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Aemann J, Spurr NK, Magee AI, Buxton RS (Jul 1992). "The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18". Genomics 13 (2): 4846. <br /><br />2. "Entrez Gene: DSG2 desmoglein 2". mutations in DSG2 contribute to the development of ARVD/C.<br /><br />3. Syrris, P., Ward, D., Asimaki, A., Evans, A., Sen-Chowdhry, S., Hughes, S. E., McKenna, W. J. Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease. Europ. Heart J. 28: 581-588, 2007.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002408-1	A02035	-	100 ug	$370		Add to Cart
BHA21002408-2	A02035-10ug	Sample	10 ug	$99		Add to Cart
BHA21002408-3	A02035-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002408-4	A02035-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002408-5	A02035-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002408-6	A02035-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002408-7	A02035-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002408-8	A02035-FITC	FITC	100 ug	$570		Add to Cart
BHA21002408-9	A02035-HRP	HRP	100 ug	$570		Add to Cart
BHA21002408-10	A02035-APC	APC	100 ug	$670		Add to Cart
BHA21002408-11	A02035-PE	PE	100 ug	$670		Add to Cart
BHA21002408-12	A02035-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002408-13	A02035-carrier-free	carrier-free	100 ug	$370		Add to Cart

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