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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Daxx Antibody Picoband®

SKU : BHA21000446

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Mfr.No.	PB9550, PB9550-10ug, PB9550-Biotin, PB9550-Cy3, PB9550-Dylight488, PB9550-Dylight550, PB9550-Dylight594, PB9550-FITC, PB9550-HRP, PB9550-APC, PB9550-PE, PB9550-iFluor647, PB9550-carrier-free
Alternative Names	Death domain-associated protein 6
Background	DAXX (death-domain associated protein) also known as DAP6 (Death-associated protein 6) or BING2, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. Human DAXX encodes a 740-amino acid polypeptide containing a nuclear localization signal. Functional analyses by Yang et al. (1997) demonstrated that Daxx binds to the Fas death domain and enhances Fas-mediated apoptosis. The authors suggested that DAXX and FADD define 2 distinct apoptotic pathways downstream of Fas. The DAXX gene is mapped to human chromosome 6p21.3 by somatic cell hybrid panels and fluorescence in situ hybridization, a region containing the HLA and putative autoimmune disease genes. MSP58 overexpression relieved DAXX-mediated transcriptional repression. Immunoprecipitation and Weste blot analysis with DAXX mutants showed that the N terminus of DAXX interacts with the C terminus of DMAP. Transient expression of DAXX or DMAP1 caused repression of glucocorticoid receptor-mediated transcription.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Daxx Antibody Picoband® catalog # PB9550. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartmen
Host	Rabbit
Immunogen Region	E.coli-derived human Daxx recombinant protein (Position: K56-R345). Human Daxx shares 88.3% and 88.6% amino acid (aa) sequence identity with mouse and rat Daxx, respectively.
Isotype	Rabbit IgG
Molecular Weight	115 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Death domain-associated protein 6;Daxx;hDaxx;ETS1-associated protein 1;EAP1;Fas death domain-associated protein;DAXX;BING2, DAP6;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9UER7
Gene Id	1616
Gene Name	DAXX
Sequence	Belongs to the DAXX family.
Subcellular Location	Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body . Nucleus, nucleolus. Chromosome, centromere. Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress. Colocalizes with RASSF1 in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat Immunocytochemistry , 0.5-1ug/ml, Human Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Chang, H. Y., Nishitoh, H., Yang, X., Ichijo, H., Baltimore, D. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281: 1860-1863, 1998. 2. Kiriakidou, M., Driscoll, D. A., Lopez-Guisa, J. M., Strauss, J. F., III. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA Cell Biol. 16: 1289-1298, 1997. 3. Yang, X., Khosravi-Far, R., Chang, H. Y., Baltimore, D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-1076, 1997.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000446-1	PB9550	100 ug	-	$370		Add to Cart
BHA21000446-2	PB9550-10ug	10 ug	Sample	$99		Add to Cart
BHA21000446-3	PB9550-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000446-4	PB9550-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000446-5	PB9550-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000446-6	PB9550-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000446-7	PB9550-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000446-8	PB9550-FITC	100 ug	FITC	$570		Add to Cart
BHA21000446-9	PB9550-HRP	100 ug	HRP	$570		Add to Cart
BHA21000446-10	PB9550-APC	100 ug	APC	$670		Add to Cart
BHA21000446-11	PB9550-PE	100 ug	PE	$670		Add to Cart
BHA21000446-12	PB9550-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000446-13	PB9550-carrier-free	100 ug	carrier-free	$370		Add to Cart

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