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Home / Primary Antibodies / Polyclonal Antibodies

Anti-D6/ACKR2 Antibody Picoband®

SKU : BHA21002129

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Mfr.No.	A05491-2, A05491-2-10ug, A05491-2-Biotin, A05491-2-Cy3, A05491-2-Dylight488, A05491-2-Dylight550, A05491-2-Dylight594, A05491-2-FITC, A05491-2-HRP, A05491-2-APC, A05491-2-PE, A05491-2-iFluor647, A05491-2-carrier-free
Alternative Names	atypical chemokine receptor 2
Background	This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-D6/ACKR2 Antibody Picoband® catalog # A05491-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transc
Host	Rabbit
Immunogen Region	E.coli-derived human D6/ACKR2 recombinant protein (Position: M138-A384).
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Atypical chemokine receptor 2; C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein 2; Chemokine-binding protein D6; ACKR2; CCBP2; CCR10; CMKBR9; D6
Tissue Specificity	Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O00590
Gene Id	1238
Gene Name	ACKR2
Subcellular Location	Cell membrane. Multi-pass membrane protein. Early endosome. Recycling endosome

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Jamieson, T., Cook, D. N., Nibbs, R. J. B., Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M., Graham, G. J. The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immun. 6: 403-411, 2005.<br /><br />2. Nibbs, R. J. B., Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D., Graham, G. J. The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J. Clin. Invest. 117: 1884-1892, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002129-1	A05491-2	-	100 ug	$370		Add to Cart
BHA21002129-2	A05491-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002129-3	A05491-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002129-4	A05491-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002129-5	A05491-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002129-6	A05491-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002129-7	A05491-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002129-8	A05491-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002129-9	A05491-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002129-10	A05491-2-APC	APC	100 ug	$670		Add to Cart
BHA21002129-11	A05491-2-PE	PE	100 ug	$670		Add to Cart
BHA21002129-12	A05491-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002129-13	A05491-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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