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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cytochrome P450 Reductase/POR Antibody Picoband®

SKU : BHA21007190

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Mfr.No.	PA1952, PA1952-10ug, PA1952-Biotin, PA1952-Cy3, PA1952-Dylight488, PA1952-Dylight550, PA1952-Dylight594, PA1952-FITC, PA1952-HRP, PA1952-APC, PA1952-PE, PA1952-iFluor647, PA1952-carrier-free
Alternative Names	NADPH--cytochrome P450 reductase
Background	POR is a membrane-boundenzyme required for electron transfer from NADPH to cytochrome P450 in the endoplasmic reticulum of theeukaryotic cell. The gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons ly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cytochrome P450 Reductase/POR Antibody catalog # PA1952. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human POR, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NADPH--cytochrome P450 reductase;CPR;P450R;1.6.2.4;POR;CYPOR;
Tissue Specificity	Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P16435
Gene Name	POR
Sequence	In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Anchored to the ER membrane by its N- terminal hydrophobic region.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, ICC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Immunocytochemistry, 0.5-1ug/ml, Human<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Adachi, M., Asakura, Y., Matsuo, M., Yamamoto, T., Hanaki, K., Arlt, W. POR R457H is a global founder mutation causing Antley-Bixler syndrome with autosomal recessive trait. (Letter) Am. J. Med. Genet. 140A: 633-635, 2006. <br /><br />2. Miller, W. L. Congenital adrenal hyperplasia. (Letter) New Eng. J. Med. 314: 1321-1322, 1986. <br /><br />3. Shephard, E. A., Phillips, I. R., Santisteban, I., West, L. F., Palmer, C. N., Ashworth, A., Povey, S. Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2. Ann. Hum. Genet. 53: 291-301, 1989.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007190-1	PA1952	-	100 ug	$370		Add to Cart
BHA21007190-2	PA1952-10ug	Sample	10 ug	$99		Add to Cart
BHA21007190-3	PA1952-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007190-4	PA1952-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007190-5	PA1952-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007190-6	PA1952-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007190-7	PA1952-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007190-8	PA1952-FITC	FITC	100 ug	$570		Add to Cart
BHA21007190-9	PA1952-HRP	HRP	100 ug	$570		Add to Cart
BHA21007190-10	PA1952-APC	APC	100 ug	$670		Add to Cart
BHA21007190-11	PA1952-PE	PE	100 ug	$670		Add to Cart
BHA21007190-12	PA1952-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007190-13	PA1952-carrier-free	carrier-free	100 ug	$370		Add to Cart

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