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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cytochrome P450 2E1/CYP2E1 Antibody Picoband®

SKU : BHA21000095

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Mfr.No.	PB9190, PB9190-10ug, PB9190-Biotin, PB9190-Cy3, PB9190-Dylight488, PB9190-Dylight550, PB9190-Dylight594, PB9190-FITC, PB9190-HRP, PB9190-APC, PB9190-PE, PB9190-iFluor647, PB9190-carrier-free
Alternative Names	Cytochrome P450 2E1
Background	Cytochrome P450 2E1 (abbreviated CYP2E1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP2E1 enzyme is encoded by the CYP2E1 gene. It is mapped to 10q26.3. While it is involved in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1. Most drugs undergo deactivation by CYP2E1, either ly or by facilitated excretion from the body. Also, many substances are bioactivated by CYP2E1 to form their active compounds. In addition, CYP2E1 is an important enzyme for the conversion of ethanol to acetaldehyde and to acetate in humans. In the conversion sequence of acetyl-CoA to glucose, CYP2E1 transforms acetone via acetol into propylene glycol and methylglyoxal, the precursors of pyruvate, acetate and lactate.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cytochrome P450 2E1/CYP2E1 Antibody Picoband® catalog # PB9190. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Host	Rabbit
Immunogen Region	E.coli-derived human CYP2E1 recombinant protein (Position: M1-Y310). Human CYP2E1 shares 73% and 74% amino acid (aa) sequences identity with mouse and rat CYP2E1, respectively.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cytochrome P450 2E1;1.14.13.-;4-nitrophenol 2-hydroxylase;1.14.13.n7;CYPIIE1;Cytochrome P450-J;Cytochrome P450 2E1, N-terminally processed;CYP2E1;CYP2E;
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Uniprot	P05181
Gene Id	1571
Gene Name	CYP2E1
Sequence	Belongs to the cytochrome P450 family.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human

Reference	1. Kölble K (December 1993). "Regional mapping of short tandem repeats on human chromosome 10: cytochrome P450 gene CYP2E, D10S196, D10S220, and D10S225". Genomics 18 (3): 7024. 2. Hayashi S, Watanabe J, Kawajiri K (October 1991). "Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene". J. Biochem. 110 (4): 55965. 3. Glew, Robert H. "You Can Get There From Here: Acetone, Anionic Ketones and Even-Carbon Fatty Acids can Provide Substrates for Gluconeogenesis". Retrieved August 2013.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000095-1	PB9190	100 ug	-	$370		Add to Cart
BHA21000095-2	PB9190-10ug	10 ug	Sample	$99		Add to Cart
BHA21000095-3	PB9190-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000095-4	PB9190-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000095-5	PB9190-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000095-6	PB9190-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000095-7	PB9190-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000095-8	PB9190-FITC	100 ug	FITC	$570		Add to Cart
BHA21000095-9	PB9190-HRP	100 ug	HRP	$570		Add to Cart
BHA21000095-10	PB9190-APC	100 ug	APC	$670		Add to Cart
BHA21000095-11	PB9190-PE	100 ug	PE	$670		Add to Cart
BHA21000095-12	PB9190-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000095-13	PB9190-carrier-free	100 ug	carrier-free	$370		Add to Cart

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