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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cytochrome P450 2E1/CYP2E1 Antibody Picoband®

SKU : BHA21007155

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Mfr.No.	PA1909, PA1909-10ug, PA1909-Biotin, PA1909-Cy3, PA1909-Dylight488, PA1909-Dylight550, PA1909-Dylight594, PA1909-FITC, PA1909-HRP, PA1909-APC, PA1909-PE, PA1909-iFluor647, PA1909-carrier-free
Alternative Names	Cytochrome P450 2E1
Background	CYP2E1, also known as P450IIE1, is a member of the P450IIE subfamily which is ethanol-inducible. It has at least 1 gene which is mapped to 10q24.3-qter, and a second is likely in rat and in man. Both the rat and human proteins encoded by this gene contain 493 amino acids and calculated molecular masses of 56,634 and 56,916 daltons, respectively. In addition, genetic polymorphisms in the 5-prime flanking region of the human P450IIE1 gene affected its binding of transacting factor and changed its transcriptional regulation, which may lead to interindividual differences of microsomal drug oxidation activity. P450IIE1 is an important enzyme for the catalysis of the conversion of ethanol to acetaldehyde and to acetate in humans,and it is also involved in the metabolism of nitrosamines. Due to the possible correlation of P450IIE1 genes with malignancy, clinical studies of RFLP pattes of these genes in cancer may be useful.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cytochrome P450 2E1/CYP2E1 Antibody catalog # PA1909. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of mouse CYP2E1, identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cytochrome P450 2E1;1.14.13.-;4-nitrophenol 2-hydroxylase;1.14.13.n7;CYPIIE1;Cytochrome P450-ALC;Cytochrome P450-J;Cyp2e1;Cyp2e, Cyp2e-1;
Tissue Specificity	Highest level in the liver and to a lesser extent in the kidney, with a higher level in the male kidney than in the female.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q05421
Gene Name	CYP2E1
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, By Heat <br>Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br>

Reference	1. Nebert, D. W.; Adesnik, M.; Coon, M. J.; Estabrook, R. W.; Gonzalez, F. J.; Guengerich, F. P.; Gunsalus, I. C.; Johnson, E. F.; Kemper, B.; Levin, W.; Phillips, I. R.; Sato, R.; Waterman, M. R. : The P450 gene superfamily: recommended nomenclature. DNA 6: 1-11, 1987.<br /><br />2. Song, B.-J.; Gelboin, H. V.; Park, S.-S.; Yang, C. S.; Gonzalez, F. J. : Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s: transcriptional and post-transcriptional regulation of the rat enzyme. J. Biol. Chem. 261: 16689-16697, 1987.<br /><br />3. Hayashi, S.; Watanabe, J.; Kawajiri, K. : Genetic polymorphisms in the 5-prime-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J. Biochem. 110: 559-565, 1991.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007155-1	PA1909	-	100 ug	$370		Add to Cart
BHA21007155-2	PA1909-10ug	Sample	10 ug	$99		Add to Cart
BHA21007155-3	PA1909-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007155-4	PA1909-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007155-5	PA1909-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007155-6	PA1909-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007155-7	PA1909-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007155-8	PA1909-FITC	FITC	100 ug	$570		Add to Cart
BHA21007155-9	PA1909-HRP	HRP	100 ug	$570		Add to Cart
BHA21007155-10	PA1909-APC	APC	100 ug	$670		Add to Cart
BHA21007155-11	PA1909-PE	PE	100 ug	$670		Add to Cart
BHA21007155-12	PA1909-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007155-13	PA1909-carrier-free	carrier-free	100 ug	$370		Add to Cart

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