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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cyclin-dependent-like kinase 5 Cdk5 Antibody Picoband®

SKU : BHA21006878

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Mfr.No.	PA1548, PA1548-10ug, PA1548-Biotin, PA1548-Cy3, PA1548-Dylight488, PA1548-Dylight550, PA1548-Dylight594, PA1548-FITC, PA1548-HRP, PA1548-APC, PA1548-PE, PA1548-iFluor647, PA1548-carrier-free
Alternative Names	Cyclin-dependent-like kinase 5
Background	CDK5, Cyclin-Dependent Kinase5, is also know as PSSALRE. The p34 (CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35 (CDK5R1). CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cyclin-dependent-like kinase 5 Cdk5 Antibody catalog # PA1548. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Proline-ed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Cdk5, identical to the related rat and mouse sequence.
Isotype	Rabbit IgG
Molecular Weight	34 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cyclin-dependent-like kinase 5;2.7.11.1;Cell division protein kinase 5;Serine/threonine-protein kinase PSSALRE;Tau protein kinase II catalytic subunit;TPKII catalytic subunit;CDK5;CDKN5;
Tissue Specificity	Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q00535
Gene Name	CDK5
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Subcellular Location	Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium . Cell projection, growth cone . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Demetrick, D. J., Zhang, H., Beach, D. H.Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.Cytogenet. Cell Genet. 66: 72-74, 1994.<br /><br />2. Ohshima, T., Nagle, J. W., Pant, H. C., Joshi, J. B., Kozak, C. A., Brady, R. O., Kulkai, A. B.Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene.Genomics 28: 585-588, 1995.<br /><br />3. Bibb, J. A., Snyder, G. L., Nishi, A., Yan, Z., Meijer, L., Fienberg, A. A., Tsai, L.-H., Kwon, Y. T., Girault, J.-A., Czeik, A. J., Huganir, R. L., Hemmings, H. C., Jr., Nai, A. C., Greengard, P.Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.Nature 402: 669-671, 1999.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006878-1	PA1548	-	100 ug	$370		Add to Cart
BHA21006878-2	PA1548-10ug	Sample	10 ug	$99		Add to Cart
BHA21006878-3	PA1548-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006878-4	PA1548-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006878-5	PA1548-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006878-6	PA1548-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006878-7	PA1548-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006878-8	PA1548-FITC	FITC	100 ug	$570		Add to Cart
BHA21006878-9	PA1548-HRP	HRP	100 ug	$570		Add to Cart
BHA21006878-10	PA1548-APC	APC	100 ug	$670		Add to Cart
BHA21006878-11	PA1548-PE	PE	100 ug	$670		Add to Cart
BHA21006878-12	PA1548-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006878-13	PA1548-carrier-free	carrier-free	100 ug	$370		Add to Cart

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