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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cyclin-dependent kinase 2 Cdk2 Antibody Picoband®

SKU : BHA21006877

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Mfr.No.	PA1547, PA1547-10ug, PA1547-Biotin, PA1547-Cy3, PA1547-Dylight488, PA1547-Dylight550, PA1547-Dylight594, PA1547-FITC, PA1547-HRP, PA1547-APC, PA1547-PE, PA1547-iFluor647, PA1547-carrier-free
Alternative Names	Cyclin-dependent kinase 2
Background	CDK2, Cyclin-Dependent Kinase2, is also know as P33. The CDK2 protein was highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1. The CDK2 gene is mapped to 12q13, the same region to which the CDK4 gene maps. Human cyclin A binds independently to 2 kinases, p34 (cdc2) or p33. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/cyclin A but not with p34 (cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34 (cdc2). P33 (cdk2) plays a unique role in cell cycle regulation of vertebrate cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cyclin-dependent kinase 2 Cdk2 Antibody catalog # PA1547. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Trig
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Cdk2, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	34 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cyclin-dependent kinase 2;2.7.11.22;Cell division protein kinase 2;p33 protein kinase;CDK2;CDKN2;
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P24941
Gene Name	CDK2
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25- (OH) (2)D (3).

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Demetrick, D. J., Zhang, H., Beach, D. H.Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.Cytogenet. Cell Genet. 66: 72-74, 1994.<br /><br />2. Tsai, L.-H., Harlow, E., Meyerson, M.Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated P33 kinase.Nature 353: 174-177, 1991.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006877-1	PA1547	-	100 ug	$370		Add to Cart
BHA21006877-2	PA1547-10ug	Sample	10 ug	$99		Add to Cart
BHA21006877-3	PA1547-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006877-4	PA1547-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006877-5	PA1547-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006877-6	PA1547-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006877-7	PA1547-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006877-8	PA1547-FITC	FITC	100 ug	$570		Add to Cart
BHA21006877-9	PA1547-HRP	HRP	100 ug	$570		Add to Cart
BHA21006877-10	PA1547-APC	APC	100 ug	$670		Add to Cart
BHA21006877-11	PA1547-PE	PE	100 ug	$670		Add to Cart
BHA21006877-12	PA1547-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006877-13	PA1547-carrier-free	carrier-free	100 ug	$370		Add to Cart

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