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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CXCR3 Antibody Picoband®

SKU : BHA21007532

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Mfr.No.	PB9079, PB9079-10ug, PB9079-Biotin, PB9079-Cy3, PB9079-Dylight488, PB9079-Dylight550, PB9079-Dylight594, PB9079-FITC, PB9079-HRP, PB9079-APC, PB9079-PE, PB9079-iFluor647, PB9079-carrier-free
Alternative Names	C-X-C chemokine receptor type 3
Background	Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. It is mapped to Xq13.1. CXCR3 is expressed on malignant B cells from chronic lymphoproliferative disorders, particularly in patients with CLL, and represents a fully functional receptor involved in chemotaxis of malignant B lymphocytes. It is found that in the absence of known etiologic agents, CXCR3 represents a novel target for therapeutic interference early in type 1 diabetes. CXCR3 signaling is associated with MG pathogenesis and proposed that and CXCR3 may serve as novel drug targets to treat MG. CXCR3A and CXCR3B are involved in the chemotactic and vascular effects of CXCL4L1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CXCR3 Antibody Picoband® catalog # PB9079. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Pr
Host	Rabbit
Immunogen Region	E.coli-derived human CXCR3 recombinant protein (Position: M1-L368). Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3.
Isotype	Rabbit IgG
Molecular Weight	41 kDa
Reactivity	Rat, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-X-C chemokine receptor type 3;CXC-R3;CXCR-3;CKR-L2;G protein-coupled receptor 9;Interferon-inducible protein 10 receptor;IP-10 receptor;CD183;CXCR3;GPR9;
Tissue Specificity	Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P49682
Gene Id	2833
Gene Name	CXCR3
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Isoform 1: Cell membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Trentin, L., Agostini, C., Facco, M., Piazza, F., Perin, A., Siviero, M., Gurrieri, C., Galvan, S., Adami, F., Zambello, R., Semenzato, G. The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis. J. Clin. Invest. 104: 115-121, 1999. 2. Frigerio, S., Junt, T., Lu, B., Gerard, C., Zumsteg, U., Hollander, G. A., Piali, L. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nature Med. 8: 1414-1420, 2002. 3. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. J. Immun. 174: 5324-5331, 2005. 4. Struyf, S., Salogni, L., Burdick, M. D., Vandercappellen, J., Gouwy, M., Noppen, S., Proost, P., Opdenakker, G., Parmentier, M., Gerard, C., Sozzani, S., Strieter, R. M., Van Damme, J. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood 117: 480-488, 2011.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007532-1	PB9079	-	100 ug	$370		Add to Cart
BHA21007532-2	PB9079-10ug	Sample	10 ug	$99		Add to Cart
BHA21007532-3	PB9079-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007532-4	PB9079-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007532-5	PB9079-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007532-6	PB9079-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007532-7	PB9079-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007532-8	PB9079-FITC	FITC	100 ug	$570		Add to Cart
BHA21007532-9	PB9079-HRP	HRP	100 ug	$570		Add to Cart
BHA21007532-10	PB9079-APC	APC	100 ug	$670		Add to Cart
BHA21007532-11	PB9079-PE	PE	100 ug	$670		Add to Cart
BHA21007532-12	PB9079-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007532-13	PB9079-carrier-free	carrier-free	100 ug	$370		Add to Cart

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