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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CXCR1 Antibody Picoband®

SKU : BHA21007288

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Mfr.No.	PA2080, PA2080-10ug, PA2080-Biotin, PA2080-Cy3, PA2080-Dylight488, PA2080-Dylight550, PA2080-Dylight594, PA2080-FITC, PA2080-HRP, PA2080-APC, PA2080-PE, PA2080-iFluor647, PA2080-carrier-free
Alternative Names	C-X-C chemokine receptor type 1
Background	CXCR1 (Chemokine,CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human gene. Morris et al. (1992) mapped the IL8RA gene to chromosome 2q35. Hartl et al. (2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CXCR1 Antibody catalog # PA2080. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR1.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-X-C chemokine receptor type 1;CXC-R1;CXCR-1;CDw128a;High affinity interleukin-8 receptor A;IL-8R A;IL-8 receptor type 1;CD181;CXCR1;CMKAR1, IL8RA;
Tissue Specificity	Endothelial tissues and brain.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P25024
Gene Name	CXCR1
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Hartl, D., Latzin, P., Hordijk, P., Marcos, V., Rudolph, C., Woischnik, M., Krauss-Etschmann, S., Koller, B., Reinhardt, D., Roscher, A. A., Roos, D., Griese, M. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nature Med. 13: 1423-1430, 2007.<br /><br />2. Morris, S. W., Nelson, N., Valentine, M. B., Shapiro, D. N., Look, A. T., Kozlosky, C. J., Beckmann, M. P., Cerretti, D. P. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. Genomics 14: 685-691, 1992.<br /><br />3. Vasilescu, A., Terashima, Y., Enomoto, M., Heath, S., Poonpiriya, V., Gatanaga, H., Do, H., Diop, G., Hirtzig, T., Auewarakul, P., Lauhakirti, D., Sura, T., Chaeau, P., Marullo, S., Therwath, A., Oka, S., Kanegasaki, S., Lathrop, M., Matsushima, K., Zagury, J.-F., Matsuda, F. A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients. Proc. Nat. Acad. Sci. 104: 3354-3359, 2007.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007288-1	PA2080	-	100 ug	$370		Add to Cart
BHA21007288-2	PA2080-10ug	Sample	10 ug	$99		Add to Cart
BHA21007288-3	PA2080-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007288-4	PA2080-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007288-5	PA2080-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007288-6	PA2080-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007288-7	PA2080-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007288-8	PA2080-FITC	FITC	100 ug	$570		Add to Cart
BHA21007288-9	PA2080-HRP	HRP	100 ug	$570		Add to Cart
BHA21007288-10	PA2080-APC	APC	100 ug	$670		Add to Cart
BHA21007288-11	PA2080-PE	PE	100 ug	$670		Add to Cart
BHA21007288-12	PA2080-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007288-13	PA2080-carrier-free	carrier-free	100 ug	$370		Add to Cart

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