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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cullin 1/Cul1 Antibody Picoband®

SKU : BHA21006886

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Mfr.No.	PA1557, PA1557-10ug, PA1557-Biotin, PA1557-Cy3, PA1557-Dylight488, PA1557-Dylight550, PA1557-Dylight594, PA1557-FITC, PA1557-HRP, PA1557-APC, PA1557-PE, PA1557-iFluor647, PA1557-carrier-free
Alternative Names	Cullin-1
Background	Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Human cullin 1, but not the other closely related cullins 2, 3, 4A, and 5, selectively interacts with human SKP1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cullin 1/Cul1 Antibody catalog # PA1557. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex,
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Cullin 1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	90 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cullin-1;CUL-1;CUL1;
Tissue Specificity	Expressed in lung fibroblasts. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q13616
Gene Name	Cul1
Sequence	Contains 1 bHLH (basic helix-loop-helix) domain.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat <br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Kipreos ET, Lander LE, Wing JP, et al. (1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.". Cell 85 (6): 82939. Bonaldo MF, Lennon G, Soares MB (1997).<br /><br />2. "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791806. <br /><br />3. Michel, J. J., Xiong, Y. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. Cell Growth Differ. 9: 435-449, 1998.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006886-1	PA1557	-	100 ug	$370		Add to Cart
BHA21006886-2	PA1557-10ug	Sample	10 ug	$99		Add to Cart
BHA21006886-3	PA1557-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006886-4	PA1557-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006886-5	PA1557-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006886-6	PA1557-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006886-7	PA1557-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006886-8	PA1557-FITC	FITC	100 ug	$570		Add to Cart
BHA21006886-9	PA1557-HRP	HRP	100 ug	$570		Add to Cart
BHA21006886-10	PA1557-APC	APC	100 ug	$670		Add to Cart
BHA21006886-11	PA1557-PE	PE	100 ug	$670		Add to Cart
BHA21006886-12	PA1557-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006886-13	PA1557-carrier-free	carrier-free	100 ug	$370		Add to Cart

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