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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CUL2 Antibody Picoband®

SKU : BHA21001905

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Mfr.No.	A02986-3, A02986-3-10ug, A02986-3-Biotin, A02986-3-Cy3, A02986-3-Dylight488, A02986-3-Dylight550, A02986-3-Dylight594, A02986-3-FITC, A02986-3-HRP, A02986-3-APC, A02986-3-PE, A02986-3-iFluor647, A02986-3-carrier-free
Alternative Names	cullin 2
Background	Cullin 2 (CUL2) is a protein that in humans is encoded by the CUL2 gene. Using immunofluorescence, it is showed that CUL2 is a cytosolic protein that can be translocated to the nucleus by VHL. By fluorescence in situ hybridization, this gene is mapped to 10p11.2-p11.1, a region reported to show loss of heterozygosity (LOH) in several forms of human cancer, including non-clear cell renal cell carcinoma. CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CUL2 Antibody Picoband® catalog # A02986-3. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of ta
Host	Rabbit
Immunogen Region	E. coli-derived human CUL2 recombinant protein (Position: E389-A745).
Isotype	Rabbit IgG
Molecular Weight	87 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cullin-2; CUL-2; CUL2
Tissue Specificity	Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q13617
Gene Id	8453
Gene Name	CUL2
Subcellular Location	Cell membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Clifford, S. C., Walsh, S., Hewson, K., Green, E. K., Brinke, A., Green, P. M., Gianelli, F., Eng, C., Maher, E. R. Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development. Genes Chromosomes Cancer 26: 20-28, 1999. <br /><br />2. Lonergan, K. M., Iliopoulos, O., Ohh, M., Kamura, T., Conaway, R. C., Conaway, J. W., Kaelin, W. G., Jr.Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Molec. Cell. Biol. 18: 732-741, 1998.<br /><br />3. Pause, A., Lee, S., Worrell, R. A., Chen, D. Y. T., Burgess, W. H., Linehan, W. M., Klausner, R. D. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Nat. Acad. Sci. 94: 2156-2161, 1997.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001905-1	A02986-3	100 ug	-	$370		Add to Cart
BHA21001905-2	A02986-3-10ug	10 ug	Sample	$99		Add to Cart
BHA21001905-3	A02986-3-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001905-4	A02986-3-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001905-5	A02986-3-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001905-6	A02986-3-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001905-7	A02986-3-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001905-8	A02986-3-FITC	100 ug	FITC	$570		Add to Cart
BHA21001905-9	A02986-3-HRP	100 ug	HRP	$570		Add to Cart
BHA21001905-10	A02986-3-APC	100 ug	APC	$670		Add to Cart
BHA21001905-11	A02986-3-PE	100 ug	PE	$670		Add to Cart
BHA21001905-12	A02986-3-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001905-13	A02986-3-carrier-free	100 ug	carrier-free	$370		Add to Cart

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