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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Crk p38 Antibody Picoband®

SKU : BHA21000011

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Mfr.No.	PB9101, PB9101-10ug, PB9101-Biotin, PB9101-Cy3, PB9101-Dylight488, PB9101-Dylight550, PB9101-Dylight594, PB9101-FITC, PB9101-HRP, PB9101-APC, PB9101-PE, PB9101-iFluor647, PB9101-carrier-free
Alternative Names	Adapter molecule crk
Background	CRK, also known as p38 or CRKII, is a protein that in humans is encoded by the CRK gene. This gene is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It is mapped to 17p13.3. The CRK protein participates in the Reelin signaling cascade downstream of DAB1. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alteative transcripts encoding different isoforms with distinct biological activity have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Crk p38 Antibody Picoband® catalog # PB9101. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytos
Host	Rabbit
Immunogen Region	E.coli-derived human Crk p38 recombinant protein (Position: A2-R246). Human Crk p38 shares 99% and 100% amino acid (aa) sequences identity with mouse and rat Crk p38, respectively.
Isotype	Rabbit IgG
Molecular Weight	34 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Adapter molecule crk;Proto-oncogene c-Crk;p38;CRK;
Tissue Specificity	Highly expressed in placenta.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P46108
Gene Id	1398
Gene Name	CRK
Sequence	Belongs to the CRK family.
Subcellular Location	Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse, Rat, By Heat

Reference	1. Mayer BJ, Hanafusa H (1990). "Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.". Proc Natl Acad Sci U S A 87 (7): 263842. 2. Matsuki T, Pramatarova A, Howell BW (June 2008). "Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis". J. Cell. Sci. 121 (Pt 11): 186975. 3. Park TJ, Curran T (December 2008). "Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway". J. Neurosci. 28 (50): 1355162.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000011-1	PB9101	100 ug	-	$370		Add to Cart
BHA21000011-3	PB9101-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000011-4	PB9101-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000011-5	PB9101-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000011-6	PB9101-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000011-7	PB9101-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000011-8	PB9101-FITC	100 ug	FITC	$570		Add to Cart
BHA21000011-9	PB9101-HRP	100 ug	HRP	$570		Add to Cart
BHA21000011-10	PB9101-APC	100 ug	APC	$670		Add to Cart
BHA21000011-11	PB9101-PE	100 ug	PE	$670		Add to Cart
BHA21000011-12	PB9101-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000011-13	PB9101-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000011-2	PB9101-10ug	10 ug	Sample	$99		Add to Cart

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