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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Coxsackie Adenovirus Receptor/CXADR Antibody Picoband®

SKU : BHA21007113

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Mfr.No.	PA1852, PA1852-10ug, PA1852-Biotin, PA1852-Cy3, PA1852-Dylight488, PA1852-Dylight550, PA1852-Dylight594, PA1852-FITC, PA1852-HRP, PA1852-APC, PA1852-PE, PA1852-iFluor647, PA1852-carrier-free
Alternative Names	Coxsackievirus and adenovirus receptor
Background	CXADR (Coxsackie virus and adenovirus receptor) is a protein that in humans is encoded by the CXADR gene, also known as CAR,CVB3-binding protein, Coxsackievirus B-adenovirus receptor. The CAR cDNA encodes a predicted 365-amino acid polypeptide that contains a single transmembrane domain and is a member of the immunoglobulin superfamily. By Northe blot analysis, they detected highest expression of 1.4-kb and 6-kb CXADR transcripts in pancreas, brain, heart, small intestine, testis, and prostate, lower expression in liver and lung, and no expression in kidney, placenta, peripheral blood leukocytes, thymus, and spleen. In comparison, mouse Cxadr showed highest expression in liver, and lower levels in kidney, heart, lung, and brain. The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins , such as: fibronectin, agrin, laminin-1 and tenascin-R.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Coxsackie Adenovirus Receptor/CXADR Antibody catalog # PA1852. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Coxsackie Adenovirus Receptor, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Coxsackievirus and adenovirus receptor;CAR;hCAR;CVB3-binding protein;Coxsackievirus B-adenovirus receptor;HCVADR;CXADR;CAR;
Tissue Specificity	Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P78310
Gene Name	CXADR
Sequence	Belongs to the peptidase C14A family.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Tomko, R. P., Xu, R., Philipson, L.HCAR and MCAR: the human and mouse receptors for subgroup C adenoviruses and group B coxsackieviruses.Proc. Nat. Acad. Sci. 94: 3352-3356, 1997.<br /><br />2. Witherden, D. A., Verdino, P., Rieder, S. E., Garijo, O., Mills, R. E., Teyton, L., Fischer, W. H., Wilson, I. A., Havran, W. L. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma-delta T cell activation. Science 329: 1205-1210, 2010. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007113-1	PA1852	-	100 ug	$370		Add to Cart
BHA21007113-2	PA1852-10ug	Sample	10 ug	$99		Add to Cart
BHA21007113-3	PA1852-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007113-4	PA1852-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007113-5	PA1852-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007113-6	PA1852-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007113-7	PA1852-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007113-8	PA1852-FITC	FITC	100 ug	$570		Add to Cart
BHA21007113-9	PA1852-HRP	HRP	100 ug	$570		Add to Cart
BHA21007113-10	PA1852-APC	APC	100 ug	$670		Add to Cart
BHA21007113-11	PA1852-PE	PE	100 ug	$670		Add to Cart
BHA21007113-12	PA1852-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007113-13	PA1852-carrier-free	carrier-free	100 ug	$370		Add to Cart

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