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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Connexin 43/GJA1 Antibody Picoband®

SKU : BHA21006624

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Mfr.No.	PA1026, PA1026-10ug, PA1026-Biotin, PA1026-Cy3, PA1026-Dylight488, PA1026-Dylight550, PA1026-Dylight594, PA1026-FITC, PA1026-HRP, PA1026-APC, PA1026-PE, PA1026-iFluor647, PA1026-carrier-free
Alternative Names	Gap junction alpha-1 protein
Background	Connexins 43 (Cx43), also called GAP Junction Protein, alpha-1 (GJA1). Connexin 43 is a member of the connexin gene family which abundantly expressed in the heart and liver and was mapped to 6q21-q23.2. Connexin43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell coupling. Mutations in the connexin43 gap-junction gene, which lead to abnormally regulated cell-cell communication, are associated with visceroatrial heterotaxia. Cx43 must also play a critical role in the physiology of hearing, presumably by participating in the recycling of potassium to the cochlear endolymph.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Connexin 43/GJA1 Antibody catalog # PA1026. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May pl
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Connexin 43, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	43 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Gap junction alpha-1 protein;Connexin-43;Cx43;Gap junction 43 kDa heart protein;GJA1;GJAL;
Tissue Specificity	Expressed in the heart and fetal cochlea. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P17302
Gene Name	GJA1
Sequence	Belongs to the connexin family. Alpha-type (group II) subfamily.
Subcellular Location	Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction . Endoplasmic reticulum .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, WB
Description	Immunofluorescence, 2ug/ml, Rat<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Britz-Cunningham, S. H.; Shah, M. M.; Zuppan, C. W.; Fletcher, W. H. : Mutations of the connexin43 gap-junction gene in patients with heart malformations and defects of laterality. New Eng. J. Med. 332: 1323-1329, 1995.<br /><br />2. Liu, X. Z.; Xia, X. J.; Adams, J.; Chen, Z. Y.; Welch, K. O.; Tekin, M.; Ouyang, X. M.; Kristiansen, A.; Pandya, A.; Balkany, T.; Aos, K. S.; Nance, W. E. : Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness. Hum. Molec. Genet. 10: 2945-2951, 2001.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006624-1	PA1026	-	100 ug	$370		Add to Cart
BHA21006624-2	PA1026-10ug	Sample	10 ug	$99		Add to Cart
BHA21006624-3	PA1026-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006624-4	PA1026-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006624-5	PA1026-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006624-6	PA1026-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006624-7	PA1026-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006624-8	PA1026-FITC	FITC	100 ug	$570		Add to Cart
BHA21006624-9	PA1026-HRP	HRP	100 ug	$570		Add to Cart
BHA21006624-10	PA1026-APC	APC	100 ug	$670		Add to Cart
BHA21006624-11	PA1026-PE	PE	100 ug	$670		Add to Cart
BHA21006624-12	PA1026-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006624-13	PA1026-carrier-free	carrier-free	100 ug	$370		Add to Cart

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