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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cofilin/CFL1 Antibody Picoband®

SKU : BHA21000522

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Mfr.No.	PB9620, PB9620-10ug, PB9620-Biotin, PB9620-Cy3, PB9620-Dylight488, PB9620-Dylight550, PB9620-Dylight594, PB9620-FITC, PB9620-HRP, PB9620-APC, PB9620-PE, PB9620-iFluor647, PB9620-carrier-free
Alternative Names	Cofilin-1
Background	Cofilin, a member of the ADF/cofilin family, is actually a protein with 70% sequence homology to ADF, making it part of the ADF/cofilin family of small ADP-binding proteins. It is a ubiquitous actin-binding factor required for the reorganization of actin filaments. The protein is known to sever actin filaments by creating more positive ends on filament fragments, it can cause depolymerization at the minus end of filaments, thereby preventing their reassembly. As a long-lasting in vivo effect, cofilin recycles older ADP-F-actin, helping cell to maintain ATP-G-actin pool for sustained motility. pH, phosphorylation and phosphoinositides regulate cofilin s binding and associating activity with actin.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cofilin/CFL1 Antibody Picoband® catalog # PB9620. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal org
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Cofilin, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	19 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cofilin-1;18 kDa phosphoprotein;p18;Cofilin, non-muscle isoform;CFL1;CFL;
Tissue Specificity	Widely distributed in various tissues.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P23528
Gene Id	1072
Gene Name	CFL1
Sequence	Contains 1 HMG box DNA-binding domain.
Subcellular Location	Nucleus matrix . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Monkey, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Cooper, G. M. and R. E. Hausman. The Cell: A Molecular Approach, 3rd ed. Washington DC: ASM Press 2004 pp.436-440. 2. Ichetovkin I, Han J, Pang KM, Knecht DA, Condeelis JS (April 2000). "Actin filaments are severed by both native and recombinant dictyostelium cofilin but to different extents". Cell Motil. Cytoskeleton 45 (4): 293306. 3. Lappalainen P, Drubin DG (July 1997). "Cofilin promotes rapid actin filament tuover in vivo".Nature 388 (6637): 7882.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000522-1	PB9620	100 ug	-	$370		Add to Cart
BHA21000522-2	PB9620-10ug	10 ug	Sample	$99		Add to Cart
BHA21000522-3	PB9620-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000522-4	PB9620-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000522-5	PB9620-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000522-6	PB9620-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000522-7	PB9620-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000522-8	PB9620-FITC	100 ug	FITC	$570		Add to Cart
BHA21000522-9	PB9620-HRP	100 ug	HRP	$570		Add to Cart
BHA21000522-10	PB9620-APC	100 ug	APC	$670		Add to Cart
BHA21000522-11	PB9620-PE	100 ug	PE	$670		Add to Cart
BHA21000522-12	PB9620-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000522-13	PB9620-carrier-free	100 ug	carrier-free	$370		Add to Cart

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