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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CIITA Antibody Picoband®

SKU : BHA21000901

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Mfr.No.	PB9996, PB9996-10ug, PB9996-Biotin, PB9996-Cy3, PB9996-Dylight488, PB9996-Dylight550, PB9996-Dylight594, PB9996-FITC, PB9996-HRP, PB9996-APC, PB9996-PE, PB9996-iFluor647, PB9996-carrier-free
Alternative Names	MHC class II transactivator
Background	CIITA is a human gene which is mapped to 16p13. This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. Also, the protein binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CIITA Antibody Picoband® catalog # PB9996. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contactin
Host	Rabbit
Immunogen Region	E.coli-derived human CIITA recombinant protein (Position: E945-R1130). Human CIITA shares 84.4% amino acid (aa) sequence identity with mouse CIITA.
Isotype	Rabbit IgG
Molecular Weight	123 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	MHC class II transactivator;CIITA;2.3.1.-;2.7.11.1;CIITA;MHC2TA;
Tissue Specificity	Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P33076
Gene Id	4261
Gene Name	CIITA
Subcellular Location	Nucleus . Nucleus, PML body . Recruited to PML body by PML.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS (Jan 2001). "Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250".Molecular Cell 7 (1): 10515. 2. Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD (Mar 2011). "MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers". Nature 471 (7338): 37781.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000901-1	PB9996	100 ug	-	$370		Add to Cart
BHA21000901-2	PB9996-10ug	10 ug	Sample	$99		Add to Cart
BHA21000901-3	PB9996-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000901-4	PB9996-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000901-5	PB9996-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000901-6	PB9996-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000901-7	PB9996-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000901-8	PB9996-FITC	100 ug	FITC	$570		Add to Cart
BHA21000901-9	PB9996-HRP	100 ug	HRP	$570		Add to Cart
BHA21000901-10	PB9996-APC	100 ug	APC	$670		Add to Cart
BHA21000901-11	PB9996-PE	100 ug	PE	$670		Add to Cart
BHA21000901-12	PB9996-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000901-13	PB9996-carrier-free	100 ug	carrier-free	$370		Add to Cart

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