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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CIITA Antibody Picoband®

SKU : BHA21004010

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Mfr.No.	A01556-3, A01556-3-10ug, A01556-3-Biotin, A01556-3-Cy3, A01556-3-Dylight488, A01556-3-Dylight550, A01556-3-Dylight594, A01556-3-FITC, A01556-3-HRP, A01556-3-APC, A01556-3-PE, A01556-3-iFluor647, A01556-3-carrier-free
Alternative Names	structural maintenance of chromosomes 6
Background	CIITA is a human gene which is mapped to 16p13. This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. Also, the protein binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CIITA Antibody Picoband® catalog # A01556-3. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The
Host	Rabbit
Immunogen Region	E.coli-derived human CIITA recombinant protein (Position: Y34-A1038).
Isotype	Rabbit IgG
Molecular Weight	123 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Structural maintenance of chromosomes protein 6; SMC protein 6; SMC-6; hSMC6; SMC6; SMC6L1
Tissue Specificity	Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P33076
Gene Id	4261
Gene Name	CIITA
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS (Jan 2001). "Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250".Molecular Cell 7 (1): 10515.<br /><br />2. Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD (Mar 2011). "MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers". Nature 471 (7338): 37781.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004010-1	A01556-3	-	100 ug	$370		Add to Cart
BHA21004010-2	A01556-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004010-3	A01556-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004010-4	A01556-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004010-5	A01556-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004010-6	A01556-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004010-7	A01556-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004010-8	A01556-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004010-9	A01556-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004010-10	A01556-3-APC	APC	100 ug	$670		Add to Cart
BHA21004010-11	A01556-3-PE	PE	100 ug	$670		Add to Cart
BHA21004010-12	A01556-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004010-13	A01556-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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