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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CHM Antibody Picoband®

SKU : BHA21002082

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Mfr.No.	A00814-2, A00814-2-10ug, A00814-2-Biotin, A00814-2-Cy3, A00814-2-Dylight488, A00814-2-Dylight550, A00814-2-Dylight594, A00814-2-FITC, A00814-2-HRP, A00814-2-APC, A00814-2-PE, A00814-2-iFluor647, A00814-2-carrier-free
Alternative Names	CHM, Rab escort protein 1
Background	Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene. It is mapped to Xq21.2. This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alteatively spliced transcript variants have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CHM Antibody Picoband® catalog # A00814-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgera
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CHM, which shares 88.9% amino acid (aa) sequence identity with both mouse and rat CHM.
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Rab proteins geranylgeranyltransferase component A 1; Choroideremia protein; Rab escort protein 1; REP-1; TCD protein; CHM; REP1; TCD
Tissue Specificity	Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P24386
Gene Id	1121
Gene Name	CHM
Subcellular Location	Cytosol.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml<br> Immunocytochemistry/Immunofluorescence, 5ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. "Entrez Gene: CHM choroideremia (Rab escort protein 1)".<br /><br />2. Molloy CM, van de Pol TJ, Brohet RM, Ropers HH, Cremers FP (May 1992). "Three RFLPs for pZ11 (DXS540) in the choroideremia gene at Xq21.2". Nucleic Acids Res. 20 (6): 1434.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002082-1	A00814-2	-	100 ug	$370		Add to Cart
BHA21002082-2	A00814-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002082-3	A00814-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002082-4	A00814-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002082-5	A00814-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002082-6	A00814-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002082-7	A00814-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002082-8	A00814-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002082-9	A00814-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002082-10	A00814-2-APC	APC	100 ug	$670		Add to Cart
BHA21002082-11	A00814-2-PE	PE	100 ug	$670		Add to Cart
BHA21002082-12	A00814-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002082-13	A00814-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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