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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CHD2 Antibody Picoband®

SKU : BHA21002479

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Mfr.No.	A04079-2, A04079-2-10ug, A04079-2-Biotin, A04079-2-Cy3, A04079-2-Dylight488, A04079-2-Dylight550, A04079-2-Dylight594, A04079-2-FITC, A04079-2-HRP, A04079-2-APC, A04079-2-PE, A04079-2-iFluor647, A04079-2-carrier-free
Alternative Names	chromodomain helicase DNA binding protein 2
Background	Chromodomain-helicase-DNA-binding protein 2 is an enzyme that in humans is encoded by the CHD2 gene. The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. CHD2 catalyzes the assembly of chromatin into periodic arrays; and the N-terminal region of CHD2, which contains tandem chromodomains, serves an auto-inhibitory role in both the DNA-binding and ATPase activities of CHD2.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CHD2 Antibody Picoband® catalog # A04079-2. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CHD2, which shares 81.8% amino acid (aa) sequence identity with both mouse and rat CHD2.
Isotype	Rabbit IgG
Molecular Weight	250 kDa
Reactivity	Human, Monkey
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Chromodomain-helicase-DNA-binding protein 2 (EC:3.6.4.12); CHD-2; ATP-dependent helicase CHD2; CHD2
Tissue Specificity	Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat glands and bronchiolar epithelium (PubMed:26911677).
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O14647
Gene Id	1106
Gene Name	CHD2
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Monkey<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Carvill, G. L., Heavin, S. B., Yendle, S. C., McMahon, J. M., O'Roak, B. J., Cook, J., Khan, A., Dorschner, M. O., Weaver, M., Calvert, S., Malone, S., Wallace, G., and 22 others. Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1. Nature Genet. 45: 825-830, 2013.<br /><br />2. Kim, Y., Khoshkhoo, S., Frankowski, J. C., Zhu, B., Abbasi, S., Lee, S., Wu, Y. E., Hunt, R. F. Chd2 is necessary for neural circuit development and long-term memory. Neuron 100: 1180-1193, 2018.<br /><br />3. Kulkai, S., Nagarajan, P., Wall, J., Donovan, D. J., Donell, R. L., Ligon, A. H., Venkatachalam, S., Quade, B. J. Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis. Am. J. Med. Genet. 146A: 1117-1127, 2008.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002479-1	A04079-2	-	100 ug	$370		Add to Cart
BHA21002479-2	A04079-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002479-3	A04079-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002479-4	A04079-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002479-5	A04079-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002479-6	A04079-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002479-7	A04079-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002479-8	A04079-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002479-9	A04079-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002479-10	A04079-2-APC	APC	100 ug	$670		Add to Cart
BHA21002479-11	A04079-2-PE	PE	100 ug	$670		Add to Cart
BHA21002479-12	A04079-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002479-13	A04079-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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