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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cdc25b Antibody Picoband®

SKU : BHA21004229

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Mfr.No.	A01899, A01899-10ug, A01899-Biotin, A01899-Cy3, A01899-Dylight488, A01899-Dylight550, A01899-Dylight594, A01899-FITC, A01899-HRP, A01899-APC, A01899-PE, A01899-iFluor647, A01899-carrier-free
Alternative Names	C-C chemokine receptor type 1
Background	Central to the onset of mitosis in all eukaryotic cells is the CDC2 protein kinase, the activity of which is negatively regulated by phosphorylation and positively activated by dephosphorylation. The latter function is carried out by a specific phosphatase, CDC25. At least 3 human CDC25 genes code for the A, B, and C forms of CDC25. CDC25B is mapped to 20p13. P38 kinase has a critical role in the initiation of a G2 delay after ultraviolet radiation. Inhibition of p38 blocks the rapid initiation of this checkpoint in both human and murine cells after ultraviolet radiation. In vitro, p38 binds and phosphorylates CDC25B at serines 309 and 361, and CDC25C at serine-216; phosphorylation of these residues is required for binding to 14-3-3 proteins. In vivo, inhibition of p38 prevents both phosphorylation of CDC25B at serine-309 and 14-3-3 binding after ultraviolet radiation, and mutation of this site is sufficient to inhibit the checkpoint initiation. Regulation of CDC25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cdc25b Antibody Picoband® catalog # A01899. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Host	Rabbit
Immunogen Region	E.coli-derived mouse Cdc25b recombinant protein (Position: D118-D339).
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	C-C chemokine receptor type 1;C-C CKR-1;CC-CKR-1;CCR-1;CCR1;Macrophage inflammatory protein 1-alpha receptor;MIP-1alpha-R;RANTES-R;CD191;Ccr1;Cmkbr1;
Tissue Specificity	Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P30306
Gene Id	12531
Gene Name	Cdc25b
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Mouse<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Bulavin, D. V., Higashimoto, Y., Popoff, I. J., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., Foace, A. J., Jr.Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.Nature 411: 102-107, 2001.<br /><br />2. Lane, S. A., Baker, E., Sutherland, G. R., Tonks, I., Hayward, N., Ellem, K.The human cell cycle gene CDC25B is located at 20p13.Genomics 15: 693-694, 1993.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004229-1	A01899	-	100 ug	$370		Add to Cart
BHA21004229-2	A01899-10ug	Sample	10 ug	$99		Add to Cart
BHA21004229-3	A01899-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004229-4	A01899-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004229-5	A01899-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004229-6	A01899-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004229-7	A01899-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004229-8	A01899-FITC	FITC	100 ug	$570		Add to Cart
BHA21004229-9	A01899-HRP	HRP	100 ug	$570		Add to Cart
BHA21004229-10	A01899-APC	APC	100 ug	$670		Add to Cart
BHA21004229-11	A01899-PE	PE	100 ug	$670		Add to Cart
BHA21004229-12	A01899-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004229-13	A01899-carrier-free	carrier-free	100 ug	$370		Add to Cart

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