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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cd70 Antibody Picoband®

SKU : BHA21004117

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Mfr.No.	A02853-2, A02853-2-10ug, A02853-2-Biotin, A02853-2-Cy3, A02853-2-Dylight488, A02853-2-Dylight550, A02853-2-Dylight594, A02853-2-FITC, A02853-2-HRP, A02853-2-APC, A02853-2-PE, A02853-2-iFluor647, A02853-2-carrier-free
Alternative Names	Melanocortin receptor 3
Background	CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cd70 Antibody Picoband® catalog # A02853-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory pattes of activity and wakefulness during periods of limited nutrient availability and f
Host	Rabbit
Immunogen Region	E.coli-derived mouse Cd70 recombinant protein (Position: C36-Q191).
Isotype	Rabbit IgG
Molecular Weight	30 kDa
Reactivity	Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	gasdermin D, gasdermin-D
Tissue Specificity	Brain, placental, and gut tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O55237
Gene Id	21948
Gene Name	Cd70
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Mouse<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Abolhassani, H., Edwards, E. S. J., Ikinciogullari, A., Jing, H., Borte, S., Buggert, M., Du, L., Matsuda-Lennikov, M., Romano, R., Caridha, R., Bade, S., Zhang, Y., and 21 others. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. J. Exp. Med. 214: 91-106, 2017.<br /><br />2. Arens, R., Tesselaar, K., Baars, P. A., van Schijndel, G. M. W., Hendriks, J., Pals, S. T., Krimpenfort, P., Borst, J., van Oers, M. H. J., van Lier, R. A. W. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFN-gamma-mediated B cell depletion. Immunity 15: 801-812, 2001. <br /><br />3. Bowman, M. R., Crimmins, M. A. V., Yetz-Aldape, J., Kriz, R., Kelleher, K., Herrmann, S. The cloning of CD70 and its identification as the ligand for CD27. J. Immun. 152: 1756-1761, 1994.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004117-1	A02853-2	-	100 ug	$370		Add to Cart
BHA21004117-2	A02853-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004117-3	A02853-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004117-4	A02853-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004117-5	A02853-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004117-6	A02853-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004117-7	A02853-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004117-8	A02853-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004117-9	A02853-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004117-10	A02853-2-APC	APC	100 ug	$670		Add to Cart
BHA21004117-11	A02853-2-PE	PE	100 ug	$670		Add to Cart
BHA21004117-12	A02853-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004117-13	A02853-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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