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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD45/PTPRC Antibody Picoband®

SKU : BHA21006915

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Mfr.No.	PA1596, PA1596-10ug, PA1596-Biotin, PA1596-Cy3, PA1596-Dylight488, PA1596-Dylight550, PA1596-Dylight594, PA1596-FITC, PA1596-HRP, PA1596-APC, PA1596-PE, PA1596-iFluor647, PA1596-carrier-free
Alternative Names	Receptor-type tyrosine-protein phosphatase C
Background	CD45 (Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase (PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase (PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 ly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD45/PTPRC Antibody catalog # PA1596. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affec
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CD45.
Isotype	Rabbit IgG
Molecular Weight	147 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Receptor-type tyrosine-protein phosphatase C;3.1.3.48;Leukocyte common antigen;L-CA;T200;CD45;PTPRC;CD45;
Tissue Specificity	Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P08575
Gene Name	PTPRC
Sequence	Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Subcellular Location	Membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br> Immunocytochemistry , 0.5-1ug/ml, Human, -<br> Immunofluorescence, 2ug/ml, Human, -<br>

Reference	1. Anderson, J.N. et al. (2004) FASEB J. 18:8.<br /><br />2. Akao, Y., Utsumi, K. R., Naito, K., Ueda, R., Takahashi, T., Yamada, K. Chromosomal assignments of genes coding for human leukocyte common antigen, T-200, and lymphocyte function-associated antigen 1, LFA-1 beta subunit. Somat. Cell Molec. Genet. 13: 273-278, 1987.<br /><br />3. Falahti, R. and D. Leitenberg (2008) J. Immunol. 181:6082.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006915-1	PA1596	-	100 ug	$370		Add to Cart
BHA21006915-2	PA1596-10ug	Sample	10 ug	$99		Add to Cart
BHA21006915-3	PA1596-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006915-4	PA1596-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006915-5	PA1596-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006915-6	PA1596-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006915-7	PA1596-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006915-8	PA1596-FITC	FITC	100 ug	$570		Add to Cart
BHA21006915-9	PA1596-HRP	HRP	100 ug	$570		Add to Cart
BHA21006915-10	PA1596-APC	APC	100 ug	$670		Add to Cart
BHA21006915-11	PA1596-PE	PE	100 ug	$670		Add to Cart
BHA21006915-12	PA1596-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006915-13	PA1596-carrier-free	carrier-free	100 ug	$370		Add to Cart

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