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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD44 Antibody Picoband®

SKU : BHA21000231

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Mfr.No.	PB9333, PB9333-10ug, PB9333-Biotin, PB9333-Cy3, PB9333-Dylight488, PB9333-Dylight550, PB9333-Dylight594, PB9333-FITC, PB9333-HRP, PB9333-APC, PB9333-PE, PB9333-iFluor647, PB9333-carrier-free
Alternative Names	CD44 antigen
Background	CD44 is also known as LHR or MC56. The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alteative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alteative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD44 Antibody Picoband® catalog # PB9333. Tested in IF, IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CD44, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	82 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	CD44 antigen;CDw44;Epican;Extracellular matrix receptor III;ECMR-III;GP90 lymphocyte homing/adhesion receptor;HUTCH-I;Heparan sulfate proteoglycan;Hermes antigen;Hyaluronate receptor;Phagocytic glycoprotein 1;PGP-1;Phagocytic glycoprotein I;PGP-I;CD44;CD44;LHR, MDU2, MDU3, MIC4;
Tissue Specificity	Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P16070
Gene Id	960
Gene Name	CD44
Sequence	Contains 1 Link domain.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Colocalizes with actin in membrane protrusions at wounding edges. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Immunofluorescence, 2ug/ml, Human, Rat

Reference	1. Fagan-Solis KD, et al. Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer. Mol Cancer, 2014 Jul 2. 2. Zhang P, et al. CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells. FEBS Lett, 2014 Dec 20.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000231-1	PB9333	100 ug	-	$370		Add to Cart
BHA21000231-2	PB9333-10ug	10 ug	Sample	$99		Add to Cart
BHA21000231-3	PB9333-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000231-4	PB9333-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000231-5	PB9333-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000231-6	PB9333-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000231-7	PB9333-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000231-8	PB9333-FITC	100 ug	FITC	$570		Add to Cart
BHA21000231-9	PB9333-HRP	100 ug	HRP	$570		Add to Cart
BHA21000231-10	PB9333-APC	100 ug	APC	$670		Add to Cart
BHA21000231-11	PB9333-PE	100 ug	PE	$670		Add to Cart
BHA21000231-12	PB9333-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000231-13	PB9333-carrier-free	100 ug	carrier-free	$370		Add to Cart

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