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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD40L/CD40LG Antibody Picoband®

SKU : BHA21006621

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Mfr.No.	PA1020, PA1020-10ug, PA1020-Biotin, PA1020-Cy3, PA1020-Dylight488, PA1020-Dylight550, PA1020-Dylight594, PA1020-FITC, PA1020-HRP, PA1020-APC, PA1020-PE, PA1020-iFluor647, PA1020-carrier-free
Alternative Names	CD40 ligand
Background	CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD40L/CD40LG Antibody catalog # PA1020. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CD40L, different from the related mouse sequence by three amino acids, rat sequence by four amino acids.
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	CD40 ligand;CD40-L;T-cell antigen Gp39;TNF-related activation protein;TRAP;Tumor necrosis factor ligand superfamily member 5;CD154;CD40 ligand, membrane form;CD40 ligand, soluble form;CD40LG;CD40L, TNFSF5, TRAP;
Tissue Specificity	Specifically expressed on activated CD4+ T- lymphocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P29965
Gene Name	CD40LG
Sequence	Belongs to the tumor necrosis factor family.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat<br>

Reference	1. Allen,R.C.;Armitage,R.J.;Conley,M.E.;Rosenblatt,H.;Jenkins,N.A.;Copeland,N.G.;Bedell, M.A.;Edelhoff,S.;Disteche,C.M.;Simoneaux,D.K.;Fanslow,W.C.;Belmont,J.;Spriggs,M.K.:CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259: 990-993, 1993.<br /><br />2. Cipollone,F.;Ferri,C.;Desideri,G.;Paloscia,L.;Materazzo,G.;Mascellanti,M.;Fazia,M.; Iezzi,A.;Cuccurullo,C.;Pini,B.;Bucci,M.;Santucci,A.;Cuccurullo,F.;Mezzetti,A.:Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty. Circulation 108: 2776-2782, 2003.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006621-1	PA1020	-	100 ug	$370		Add to Cart
BHA21006621-2	PA1020-10ug	Sample	10 ug	$99		Add to Cart
BHA21006621-3	PA1020-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006621-4	PA1020-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006621-5	PA1020-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006621-6	PA1020-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006621-7	PA1020-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006621-8	PA1020-FITC	FITC	100 ug	$570		Add to Cart
BHA21006621-9	PA1020-HRP	HRP	100 ug	$570		Add to Cart
BHA21006621-10	PA1020-APC	APC	100 ug	$670		Add to Cart
BHA21006621-11	PA1020-PE	PE	100 ug	$670		Add to Cart
BHA21006621-12	PA1020-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006621-13	PA1020-carrier-free	carrier-free	100 ug	$370		Add to Cart

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