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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD40 Antibody Picoband®

SKU : BHA21006619

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Mfr.No.	PA1019, PA1019-10ug, PA1019-Biotin, PA1019-Cy3, PA1019-Dylight488, PA1019-Dylight550, PA1019-Dylight594, PA1019-FITC, PA1019-HRP, PA1019-APC, PA1019-PE, PA1019-iFluor647, PA1019-carrier-free
Alternative Names	Tumor necrosis factor receptor superfamily member 5
Background	CD40 is a cell surface receptor that is expressed on the surface of all mature B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily and is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD40 Antibody catalog # PA1019. Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD40.
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Cd40;Tnfrsf5;
Tissue Specificity	B-lymphocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.01mg NaN3.

Uniprot	P27512
Gene Name	CD40
Sequence	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Subcellular Location	Isoform I: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse<br>

Reference	1. Clark, E. A. : CD40: a cytokine receptor in search of a ligand. Tissue Antigens 35: 33-36, 1990.<br /><br />2. Harding, S. A.; Sarma, J.; Josephs, D. H.; Cruden, N. L.; Din, J. N.; Twomey, P. J.; Fox, K. A. A.; Newby, D. E. : Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers. Circulation 109: 1926-1929, 2004. <br /><br />3. Stamenkovic, I.; Clark, E. A.; Seed, B. : A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8: 1403-1410, 1989. <br /><br />4. van Kooten, C.; Banchereau, J. : CD40-CD40 ligand. J. Leuko. Biol. 67: 2-17, 2000. <br /><br />5. Kato, K.; Cantwell, M. J.; Sharma, S.; Kipps, T. J. : Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. J. Clin. Invest. 101: 1133-1141, 1998. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006619-1	PA1019	-	100 ug	$370		Add to Cart
BHA21006619-2	PA1019-10ug	Sample	10 ug	$99		Add to Cart
BHA21006619-3	PA1019-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006619-4	PA1019-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006619-5	PA1019-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006619-6	PA1019-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006619-7	PA1019-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006619-8	PA1019-FITC	FITC	100 ug	$570		Add to Cart
BHA21006619-9	PA1019-HRP	HRP	100 ug	$570		Add to Cart
BHA21006619-10	PA1019-APC	APC	100 ug	$670		Add to Cart
BHA21006619-11	PA1019-PE	PE	100 ug	$670		Add to Cart
BHA21006619-12	PA1019-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006619-13	PA1019-carrier-free	carrier-free	100 ug	$370		Add to Cart

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