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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD31/PECAM1 Antibody Picoband®

SKU : BHA21000005

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Mfr.No.	PB9094, PB9094-10ug, PB9094-Biotin, PB9094-Cy3, PB9094-Dylight488, PB9094-Dylight550, PB9094-Dylight594, PB9094-FITC, PB9094-HRP, PB9094-APC, PB9094-PE, PB9094-iFluor647, PB9094-carrier-free
Alternative Names	Platelet endothelial cell adhesion molecule
Background	CD31 also known as Platelet endothelial cell adhesion molecule (PECAM-1), is a protein that in human is encoded by the PECAM1 gene. Encoded protein is a member of the immunoglobulin superfamily, CD31 is mapped to 17q23.3. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. It is demonstrated that CD31 expression on human PBSCs may positively affect both neutrophil and platelet engraftment. Meanwhile, CD31 is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD31/PECAM1 Antibody Picoband® catalog # PB9094. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient traff
Host	Rabbit
Immunogen Region	E.coli-derived human CD31 recombinant protein (Position: Q28-G382). Human CD31 shares 65% and 68% amino acid (aa) sequences identity with mouse and rat CD31, respectively.
Isotype	Rabbit IgG
Molecular Weight	90 kDa, 130 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Platelet endothelial cell adhesion molecule;PECAM-1;EndoCAM;GPIIA';PECA1;CD31;PECAM1;
Tissue Specificity	Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level). .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P16284
Gene Id	5175
Gene Name	PECAM1
Sequence	Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Subcellular Location	Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, By Heat Flow Cytometry(Fixed), 1-3 ug/1x10⁶ cells

Reference	1. Newman PJ, Bedt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science 247 (4947): 121922. 2. Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics 34 (2): 22932. 3. Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics 37 (2): 2268. 4. Kellermair J, Redwan B, Alias S, Jabkowski J, Panzenboeck A, Kellermair L, Winter MP, Weltermann A, Lang IM."Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution."2013 Nov 7; 122(19):3376-84. 5. Donmez A, Tombuloglu M, Gulbahar O, Arik B, Cagirgan S, Vural F, Gokmen N."CD31 expression on peripheral blood stem cells predicts both early neutrophil and platelet engraftments."2013 Oct;49(2):307-12.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000005-1	PB9094	100 ug	-	$370		Add to Cart
BHA21000005-3	PB9094-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000005-4	PB9094-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000005-5	PB9094-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000005-6	PB9094-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000005-7	PB9094-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000005-8	PB9094-FITC	100 ug	FITC	$570		Add to Cart
BHA21000005-9	PB9094-HRP	100 ug	HRP	$570		Add to Cart
BHA21000005-10	PB9094-APC	100 ug	APC	$670		Add to Cart
BHA21000005-11	PB9094-PE	100 ug	PE	$670		Add to Cart
BHA21000005-12	PB9094-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000005-13	PB9094-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000005-2	PB9094-10ug	10 ug	Sample	$99		Add to Cart

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