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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD272/BTLA Antibody Picoband®

SKU : BHA21002048

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Mfr.No.	A03149, A03149-10ug, A03149-Biotin, A03149-Cy3, A03149-Dylight488, A03149-Dylight550, A03149-Dylight594, A03149-FITC, A03149-HRP, A03149-APC, A03149-PE, A03149-iFluor647, A03149-carrier-free
Alternative Names	B and T lymphocyte associated
Background	B- and T-lymphocyte attenuator is a protein that in humans is encoded by the BTLA gene. BTLA has also been designated as CD272 (cluster of differentiation 272). This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alteative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CD272/BTLA Antibody Picoband® catalog # A03149. Tested in Flow Cytometry, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human CD272/BTLA.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD272; BTLA
Tissue Specificity	Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q7Z6A9
Gene Id	151888
Gene Name	BTLA
Subcellular Location	Membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br> Immunocytochemistry, 0.5-1ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells

Reference	1. Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM (July 2003). <br /><br />2. "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 6709.<br /><br />3. "Entrez Gene: BTLA B and T lymphocyte associated".

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002048-1	A03149	-	100 ug	$370		Add to Cart
BHA21002048-2	A03149-10ug	Sample	10 ug	$99		Add to Cart
BHA21002048-3	A03149-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002048-4	A03149-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002048-5	A03149-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002048-6	A03149-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002048-7	A03149-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002048-8	A03149-FITC	FITC	100 ug	$570		Add to Cart
BHA21002048-9	A03149-HRP	HRP	100 ug	$570		Add to Cart
BHA21002048-10	A03149-APC	APC	100 ug	$670		Add to Cart
BHA21002048-11	A03149-PE	PE	100 ug	$670		Add to Cart
BHA21002048-12	A03149-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002048-13	A03149-carrier-free	carrier-free	100 ug	$370		Add to Cart

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