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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD22 Antibody Picoband®

SKU : BHA21000591

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Mfr.No.	PB9691, PB9691-10ug, PB9691-Biotin, PB9691-Cy3, PB9691-Dylight488, PB9691-Dylight550, PB9691-Dylight594, PB9691-FITC, PB9691-HRP, PB9691-APC, PB9691-PE, PB9691-iFluor647, PB9691-carrier-free
Alternative Names	B-cell receptor CD22
Background	CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. It is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. The human CD22 gene is expressed specifically in B lymphocytes and likely has an important function in cell-cell interactions. The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor. And CD22 is located within the band region q13.1 of chromosome 19.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD22 Antibody Picoband® catalog # PB9691. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be ma
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CD22, different from the related mouse sequence by ten amino acids.
Isotype	Rabbit IgG
Molecular Weight	140 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;CD22;SIGLEC2;
Tissue Specificity	B-lymphocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P20273
Gene Id	933
Gene Name	CD22
Subcellular Location	Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Flow Cytometry, 1-3ug/1x10⁶cells, Human

Reference	1. John, B.; Herrin, B. R.; Raman, C.; Wang, Y.; Bobbitt, K. R.; Brody, B. A.; Justement, L. B. The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J. Immun. 170: 3534-3543, 2003. 2. O'Keefe, T. L.; Williams, G. T.; Davies, S. L.; Neuberger, M. S. Hyperresponsive B cells in CD22-deficient mice. Science 274: 798-801, 1996. 3. Wilson, G. L.; Najfeld, V.; Kozlow, E.; Menniger, J.; Ward, D.; Kehrl, J. H. Genomic structure and chromosomal mapping of the human CD22 gene. J. Immun. 150: 5013-5024, 1993.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000591-1	PB9691	100 ug	-	$370		Add to Cart
BHA21000591-2	PB9691-10ug	10 ug	Sample	$99		Add to Cart
BHA21000591-3	PB9691-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000591-4	PB9691-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000591-5	PB9691-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000591-6	PB9691-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000591-7	PB9691-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000591-8	PB9691-FITC	100 ug	FITC	$570		Add to Cart
BHA21000591-9	PB9691-HRP	100 ug	HRP	$570		Add to Cart
BHA21000591-10	PB9691-APC	100 ug	APC	$670		Add to Cart
BHA21000591-11	PB9691-PE	100 ug	PE	$670		Add to Cart
BHA21000591-12	PB9691-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000591-13	PB9691-carrier-free	100 ug	carrier-free	$370		Add to Cart

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