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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD1D Antibody Picoband®

SKU : BHA21002398

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Mfr.No.	A00323, A00323-10ug, A00323-Biotin, A00323-Cy3, A00323-Dylight488, A00323-Dylight550, A00323-Dylight594, A00323-FITC, A00323-HRP, A00323-APC, A00323-PE, A00323-iFluor647, A00323-carrier-free
Alternative Names	CD1d molecule
Background	CD1D (CD1d molecule) also known as R3G1, Antigen-presenting glycoprotein CD1d, R3G1, CD1D, is the sole group-2 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins. Expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules. CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production. Jayawardena-Wolf et al. described 2 different pathways of Cd1d trafficking to endosomal compartments in mouse cells. A tyrosine-based motif goves recycling between the plasma membrane and the endosome, while Cd1d associates, like major histocompatibility complex class II antigens, with the invariant chain, or II, in the endoplasmic reticulum. Both pathways enhance antigen presentation to Cd1d-restricted natural killer T cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CD1D Antibody Picoband® catalog # A00323. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
Host	Rabbit
Immunogen Region	E.coli-derived human CD1D recombinant protein (Position: E20-W295).
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Antigen-presenting glycoprotein CD1d; R3G1; CD1d; CD1D
Tissue Specificity	Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P15813
Gene Id	912
Gene Name	CD1D
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cell membrane; Basolateral cell membrane; Lysosome membrane; Endosome membrane

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, WB
Description	"Weste blot, 0.25-0.5ug/ml, Human, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>"

Reference	1. Jayawardena-Wolf, J., Benlagha, K., Chiu, Y.-H., Mehr, R., Bendelac, A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain.Immunity 15: 897-908, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002398-1	A00323	-	100 ug	$370		Add to Cart
BHA21002398-2	A00323-10ug	Sample	10 ug	$99		Add to Cart
BHA21002398-3	A00323-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002398-4	A00323-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002398-5	A00323-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002398-6	A00323-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002398-7	A00323-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002398-8	A00323-FITC	FITC	100 ug	$570		Add to Cart
BHA21002398-9	A00323-HRP	HRP	100 ug	$570		Add to Cart
BHA21002398-10	A00323-APC	APC	100 ug	$670		Add to Cart
BHA21002398-11	A00323-PE	PE	100 ug	$670		Add to Cart
BHA21002398-12	A00323-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002398-13	A00323-carrier-free	carrier-free	100 ug	$370		Add to Cart

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