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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD1a Antibody Picoband®

SKU : BHA21007132

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Mfr.No.	PA1875, PA1875-10ug, PA1875-Biotin, PA1875-Cy3, PA1875-Dylight488, PA1875-Dylight550, PA1875-Dylight594, PA1875-FITC, PA1875-HRP, PA1875-APC, PA1875-PE, PA1875-iFluor647, PA1875-carrier-free
Alternative Names	T-cell surface glycoprotein CD1a
Background	CD1A (Thymocyte antigen CD1A) also known as CD1, is a human protein encoded by the CD1A gene. CD1A is 1 of 5 distinct CD1 genes that are variably conserved in different mammalian species. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.The CD1A gene is mapped on 1q23.1. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. CD1A is concentrated in the early or recycling endosome. Moody et al. (2004) reported that CD1A presents to T cells a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Apolipoprotein E (107741) binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 in antigen-presenting cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD1a Antibody catalog # PA1875. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human CD1a.
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	T-cell surface glycoprotein CD1a;T-cell surface antigen T6/Leu-6;hTa1 thymocyte antigen;CD1a;CD1A;
Tissue Specificity	Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P06126
Gene Name	CD1A
Sequence	Contains 9 SRCR domains.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Martin, L. H., Calabi, F., Lefebvre, F.-A., Bilsland, C. A. G., Milstein, C. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.Proc. Nat. Acad. Sci. 84: 9189-9193, 1987.<br /><br />2. Moody, D. B., Young, D. C., Cheng, T.-Y., Rosat, J.-P., Roura-mir, C., O'Connor, P. B., Zajonc, D. M., Walz, A., Miller, M. J., Levery, S. B., Wilson, I. A., Costello, C. E., Brenner, M. B. T cell activation by lipopeptide antigens. Science 303: 527-531, 2004. Note: Erratum: Science 304: 211 only, 2004. <br /><br />3. Park, S.-H., Bendelac, A. CD1-restricted T-cell responses and microbial infection. Nature 406: 788-792, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007132-1	PA1875	-	100 ug	$370		Add to Cart
BHA21007132-2	PA1875-10ug	Sample	10 ug	$99		Add to Cart
BHA21007132-3	PA1875-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007132-4	PA1875-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007132-5	PA1875-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007132-6	PA1875-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007132-7	PA1875-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007132-8	PA1875-FITC	FITC	100 ug	$570		Add to Cart
BHA21007132-9	PA1875-HRP	HRP	100 ug	$570		Add to Cart
BHA21007132-10	PA1875-APC	APC	100 ug	$670		Add to Cart
BHA21007132-11	PA1875-PE	PE	100 ug	$670		Add to Cart
BHA21007132-12	PA1875-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007132-13	PA1875-carrier-free	carrier-free	100 ug	$370		Add to Cart

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