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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD168/HMMR Antibody Picoband®

SKU : BHA21006911

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Mfr.No.	PA1592, PA1592-10ug, PA1592-Biotin, PA1592-Cy3, PA1592-Dylight488, PA1592-Dylight550, PA1592-Dylight594, PA1592-FITC, PA1592-HRP, PA1592-APC, PA1592-PE, PA1592-iFluor647, PA1592-carrier-free
Alternative Names	Hyaluronan mediated motility receptor
Background	HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alteative splicing have been observed, but not thoroughly studied.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD168/HMMR Antibody catalog # PA1592. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CD168.
Isotype	Rabbit IgG
Molecular Weight	84 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Hyaluronan mediated motility receptor;Intracellular hyaluronic acid-binding protein;Receptor for hyaluronan-mediated motility;CD168;HMMR;IHABP, RHAMM;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O75330
Gene Name	HMMR
Subcellular Location	Cell surface. Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Entwistle, J., Zhang, S., Yang, B., Wong, C., Li, Q., Hall, C. L., Jingbo, A., Mowat, M., Greenberg, A. H., Turley, E. A.Characterization of the murine gene encoding the hyaluronan receptor RHAMM.Gene 163: 233-238, 1995.<br /><br />2. Hall, C., Yang, B., Yang, X., Zhang, S., Turley, M., Samuel, S., Lange, L. A., Wang, C., Curpen, G. D., Savani, R. C., Greenberg, A. H., Turley, E. A.Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation.Cell 82: 19-28, 1995.<br /><br />3. Savani, R. C., Wang, C., Yang, B. H., Zhang, S. W., Kinsella, M. G., Wight, T. N., Ste, R., Nance, D. M., Turley, E. A.Migration of bovine aortic smooth muscle cells after wounding injury: the role of hyaluronan and RHAMM.J. Clin. Invest. 95: 1158-1168, 1995.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006911-1	PA1592	-	100 ug	$370		Add to Cart
BHA21006911-2	PA1592-10ug	Sample	10 ug	$99		Add to Cart
BHA21006911-3	PA1592-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006911-4	PA1592-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006911-5	PA1592-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006911-6	PA1592-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006911-7	PA1592-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006911-8	PA1592-FITC	FITC	100 ug	$570		Add to Cart
BHA21006911-9	PA1592-HRP	HRP	100 ug	$570		Add to Cart
BHA21006911-10	PA1592-APC	APC	100 ug	$670		Add to Cart
BHA21006911-11	PA1592-PE	PE	100 ug	$670		Add to Cart
BHA21006911-12	PA1592-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006911-13	PA1592-carrier-free	carrier-free	100 ug	$370		Add to Cart

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